SMC5

Structural maintenance of chromosomes 5

Identifiers

SMC5 ; SMC5L1

External IDs

OMIM: 609386 MGI: 2385088 HomoloGene: 41009 GeneCards: SMC5 Gene

Gene ontology
Molecular function	• protein binding • ATP binding
Cellular component	• chromosome, telomeric region • nucleus • nucleolus • PML body • cell junction • Smc5-Smc6 complex
Biological process	• telomere maintenance via recombination • double-strand break repair via homologous recombination • double-strand break repair via nonhomologous end joining • mitotic nuclear division • positive regulation of maintenance of mitotic sister chromatid cohesion • positive regulation of mitotic metaphase/anaphase transition • cellular senescence
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
72.87 – 72.97 Mb

Chr 19:
23.21 – 23.27 Mb

PubMed search

Structural maintenance of chromosomes protein 5 is a protein encoded by the SMC5 gene in human.^[1]^[2]

References

↑ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
↑ "Entrez Gene: SMC5 structural maintenance of chromosomes 5".

Nakajima D, Okazaki N, Yamakawa H et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Taylor EM, Moghraby JS, Lees JH et al. (2001). "Characterization of a Novel Human SMC Heterodimer Homologous to the Schizosaccharomyces pombe Rad18/Spr18 Complex". Mol. Biol. Cell 12 (6): 1583–94. doi:10.1091/mbc.12.6.1583. PMC 37326. PMID 11408570.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Potts PR, Yu H (2005). "Human MMS21/NSE2 Is a SUMO Ligase Required for DNA Repair". Mol. Cell. Biol. 25 (16): 7021–32. doi:10.1128/MCB.25.16.7021-7032.2005. PMC 1190242. PMID 16055714.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Potts PR, Porteus MH, Yu H (2006). "Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks". EMBO J. 25 (14): 3377–88. doi:10.1038/sj.emboj.7601218. PMC 1523187. PMID 16810316.
Potts PR, Yu H (2007). "The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins". Nat. Struct. Mol. Biol. 14 (7): 581–90. doi:10.1038/nsmb1259. PMID 17589526.

Structures of the cell nucleus / nuclear protein

Envelope (membrane)/
nuclear lamina

Pore complex:
Nucleoporin
- NUP35
- NUP37
- NUP43
- NUP50
- NUP54
- NUP62
- NUP85
- NUP88
- NUP93
- NUP98
- NUP107
- NUP133
- NUP153
- NUP155
- NUP160
- NUP188
- NUP205
- NUP210
- NUP214
AAAS

Nucleolus

Cajal (coiled) body
- GEMIN4
- GEMIN5
- GEMIN6
- GEMIN7
- GEMIN8
- SMN/SIP1
- COIL
Perinucleolar compartment
- PTBP1
- CUGBP1
TCOF
ATXN7

Other

Chromatin Dot (PML body) Paraspeckle

SMC protein:	Cohesin SMC1A SMC1B SMC3 Condensin NCAPD2 NCAPD3 NCAPG NCAPG2 NCAPH NCAPH2 SMC2 SMC4 DNA repair SMC5 SMC6

Transition nuclear protein:	TNP1 TNP2

Nuclear matrix (Nucleoskeleton) Nucleoplasm Nucleosol

LITAF

see also transcription factors and intracellular receptors

see also nucleus diseases

Index of cells

Description	Structure nucleus chromosome genetics Organelles peroxisome cytoskeleton centrosome epithelia cilia mitochondria Membranes proteins cell adhesions Membrane transport ion channels vesicular transport solute carrier ABC transporters ATPase oxidoreduction-driven

Disease	Structural peroxisome cytoskeleton cilia mitochondria nucleus scleroprotein Membrane channelopathy solute carrier ATPase ABC transporters other extracellular ligands cell surface receptors intracellular signalling Vesicular transport Pore-forming toxins

SMC5

References

Further reading