SMARCA5

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

Identifiers

SMARCA5 ; ISWI; SNF2H; WCRF135; hISWI; hSNF2H

External IDs

OMIM: 603375 MGI: 1935129 HomoloGene: 55764 GeneCards: SMARCA5 Gene

Gene ontology
Molecular function	• DNA binding • helicase activity • protein binding • ATP binding • ATPase activity • nucleosome binding • histone binding
Cellular component	• condensed chromosome • nucleus • nucleoplasm • chromatin silencing complex • NURF complex • RSF complex • nuclear replication fork
Biological process	• chromatin silencing at rDNA • ATP catabolic process • double-strand break repair • nucleosome assembly • chromatin remodeling • DNA-templated transcription, initiation • regulation of transcription from RNA polymerase II promoter • embryo development • nucleosome positioning • centromere-specific nucleosome assembly • ATP-dependent chromatin remodeling
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
144.43 – 144.48 Mb

Chr 8:
80.7 – 80.74 Mb

PubMed search

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 is a protein that in humans is encoded by the SMARCA5 gene.^[1]^[2]

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.^[2]

Interactions

SMARCA5 has been shown to interact with RAD21,^[3] Histone deacetylase 2,^[3] POLE3,^[4] SATB1^[5] and BAZ1A.^[3]^[4]^[5]^[6]^[7]

References

↑ Aihara T, Miyoshi Y, Koyama K, Suzuki M, Takahashi E, Monden M, Nakamura Y (October 1998). "Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI". Cytogenet Cell Genet 81 (3–4): 191–3. doi:10.1159/000015027. PMID 9730600.
↑ 2.0 2.1 "Entrez Gene: SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5".
↑ 3.0 3.1 3.2 Hakimi, Mohamed-Ali; Bochar Daniel A; Schmiesing John A; Dong Yuanshu; Barak Orr G; Speicher David W; Yokomori Kyoko; Shiekhattar Ramin (August 2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature (England) 418 (6901): 994–8. doi:10.1038/nature01024. ISSN 0028-0836. PMID 12198550.
↑ 4.0 4.1 Poot, R A; Dellaire G; Hülsmann B B; Grimaldi M A; Corona D F; Becker P B; Bickmore W A; Varga-Weisz P D (July 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. (ENGLAND) 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. ISSN 0261-4189. PMC 313940. PMID 10880450.
↑ 5.0 5.1 Yasui, Dag; Miyano Masaru, Cai Shutao, Varga-Weisz Patrick, Kohwi-Shigematsu Terumi (October 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature (England) 419 (6907): 641–5. doi:10.1038/nature01084. ISSN 0028-0836. PMID 12374985.
↑ Bochar, D A; Savard J; Wang W; Lafleur D W; Moore P; Côté J; Shiekhattar R (February 2000). "A family of chromatin remodeling factors related to Williams syndrome transcription factor". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (3): 1038–43. doi:10.1073/pnas.97.3.1038. ISSN 0027-8424. PMC 15513. PMID 10655480.
↑ Bozhenok, Ludmila; Wade Paul A, Varga-Weisz Patrick (May 2002). "WSTF–ISWI chromatin remodeling complex targets heterochromatic replication foci". EMBO J. (England) 21 (9): 2231–41. doi:10.1093/emboj/21.9.2231. ISSN 0261-4189. PMC 125993. PMID 11980720.

Dirscherl SS, Krebs JE (2005). "Functional diversity of ISWI complexes". Biochem. Cell Biol. 82 (4): 482–9. doi:10.1139/o04-044. PMID 15284901.
LeRoy G, Orphanides G, Lane WS, Reinberg D (1998). "Requirement of RSF and FACT for transcription of chromatin templates in vitro". Science 282 (5395): 1900–4. doi:10.1126/science.282.5395.1900. PMID 9836642.
Bochar DA, Savard J, Wang W et al. (2000). "A family of chromatin remodeling factors related to Williams syndrome transcription factor". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1038–43. doi:10.1073/pnas.97.3.1038. PMC 15513. PMID 10655480.
Poot RA, Dellaire G, Hülsmann BB et al. (2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.
Stopka T, Zakova D, Fuchs O et al. (2000). "Chromatin remodeling gene SMARCA5 is dysregulated in primitive hematopoietic cells of acute leukemia". Leukemia 14 (7): 1247–52. doi:10.1038/sj.leu.2401807. PMID 10914549.
Aalfs JD, Narlikar GJ, Kingston RE (2001). "Functional differences between the human ATP-dependent nucleosome remodeling proteins BRG1 and SNF2H". J. Biol. Chem. 276 (36): 34270–8. doi:10.1074/jbc.M104163200. PMID 11435432.
Strohner R, Nemeth A, Jansa P et al. (2001). "NoRC—a novel member of mammalian ISWI-containing chromatin remodeling machines". EMBO J. 20 (17): 4892–900. doi:10.1093/emboj/20.17.4892. PMC 125270. PMID 11532953.
Bozhenok L, Wade PA, Varga-Weisz P (2002). "WSTF–ISWI chromatin remodeling complex targets heterochromatic replication foci". EMBO J. 21 (9): 2231–41. doi:10.1093/emboj/21.9.2231. PMC 125993. PMID 11980720.
Levine SS, Weiss A, Erdjument-Bromage H et al. (2002). "The Core of the Polycomb Repressive Complex Is Compositionally and Functionally Conserved in Flies and Humans". Mol. Cell. Biol. 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
Hakimi MA, Bochar DA, Schmiesing JA et al. (2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature 418 (6901): 994–8. doi:10.1038/nature01024. PMID 12198550.
Yasui D, Miyano M, Cai S et al. (2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature 419 (6907): 641–5. doi:10.1038/nature01084. PMID 12374985.
Collins N, Poot RA, Kukimoto I et al. (2003). "An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin". Nat. Genet. 32 (4): 627–32. doi:10.1038/ng1046. PMID 12434153.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Loyola A, Huang JY, LeRoy G et al. (2003). "Functional Analysis of the Subunits of the Chromatin Assembly Factor RSF". Mol. Cell. Biol. 23 (19): 6759–68. doi:10.1128/MCB.23.19.6759-6768.2003. PMC 193931. PMID 12972596.
Shu H, Chen S, Bi Q et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Mol. Cell Proteomics 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
Obuse C, Yang H, Nozaki N et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
Geiman TM, Sankpal UT, Robertson AK et al. (2004). "DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system". Biochem. Biophys. Res. Commun. 318 (2): 544–55. doi:10.1016/j.bbrc.2004.04.058. PMID 15120635.
Geiman TM, Sankpal UT, Robertson AK et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Res. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.

SMARCA5

Interactions

References

Further reading