SMARCA2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

PDB rendering based on 2dat.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2DAT

Identifiers

Symbols

SMARCA2 ; BAF190; BRM; NCBRS; SNF2; SNF2L2; SNF2LA; SWI2; Sth1p; hBRM; hSNF2a

External IDs

OMIM: 600014 MGI: 99603 HomoloGene: 2308 IUPHAR: 2739 GeneCards: SMARCA2 Gene

Gene ontology
Molecular function	• RNA polymerase II transcription coactivator activity • transcription coactivator activity • helicase activity • protein binding • ATP binding • DNA-dependent ATPase activity • histone binding • transcription regulatory region DNA binding
Cellular component	• nuclear chromatin • nucleus • nucleoplasm • nucleolus • SWI/SNF complex • intracellular membrane-bounded organelle • intermediate filament cytoskeleton • npBAF complex • nBAF complex
Biological process	• negative regulation of transcription from RNA polymerase II promoter • ATP catabolic process • chromatin remodeling • transcription, DNA-templated • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • nervous system development • negative regulation of cell proliferation • negative regulation of cell growth • aortic smooth muscle cell differentiation • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
2.02 – 2.19 Mb

Chr 19:
26.61 – 26.78 Mb

PubMed search

Probable global transcription activator SNF2L2 is a protein that in humans is encoded by the SMARCA2 gene.^[1]^[2]

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.^[2]

Interactions

SMARCA2 has been shown to interact with SS18,^[3] ACTL6A,^[4]^[5]^[6] SIN3A,^[7] POLR2A,^[4]^[7]^[8] Prohibitin,^[9] SMARCC1,^[4]^[7] CEBPB,^[10] SMARCB1^[4]^[7] and ARID1B.^[11]

References

↑ Muchardt C, Yaniv M, Mattei MG (July 1994). "Assignment of HBRM, the human homolog of S. cerevisiae SNF2/SWI2 and Drosophila brm genes, to chromosome region 9p23-p24, by in situ hybridization". Mamm Genome 5 (4): 241–3. doi:10.1007/BF00360554. PMID 8012116.
↑ 2.0 2.1 "Entrez Gene: SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2".
↑ Perani, Michela; Ingram Catherine J E; Cooper Colin S; Garrett Michelle D; Goodwin Graham H (November 2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers". Oncogene (England) 22 (50): 8156–67. doi:10.1038/sj.onc.1207031. ISSN 0950-9232. PMID 14603256.
↑ 4.0 4.1 4.2 4.3 Wang, W; Côté J, Xue Y, Zhou S, Khavari P A, Biggar S R, Muchardt C, Kalpana G V, Goff S P, Yaniv M, Workman J L, Crabtree G R (October 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. (ENGLAND) 15 (19): 5370–82. ISSN 0261-4189. PMC 452280. PMID 8895581.
↑ Park, Jeonghyeon; Wood Marcelo A; Cole Michael D (March 2002). "BAF53 Forms Distinct Nuclear Complexes and Functions as a Critical c-Myc-Interacting Nuclear Cofactor for Oncogenic Transformation". Mol. Cell. Biol. (United States) 22 (5): 1307–16. doi:10.1128/MCB.22.5.1307-1316.2002. ISSN 0270-7306. PMC 134713. PMID 11839798.
↑ Kuroda, Yukiko; Oma Yukako; Nishimori Katsuhiko; Ohta Tsutomu; Harata Masahiko (November 2002). "Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex". Biochem. Biophys. Res. Commun. (United States) 299 (2): 328–34. doi:10.1016/S0006-291X(02)02637-2. ISSN 0006-291X. PMID 12437990.
↑ 7.0 7.1 7.2 7.3 Sif, S; Saurin A J; Imbalzano A N; Kingston R E (March 2001). "Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes". Genes Dev. (United States) 15 (5): 603–18. doi:10.1101/gad.872801. ISSN 0890-9369. PMC 312641. PMID 11238380.
↑ Cho, H; Orphanides G; Sun X; Yang X J; Ogryzko V; Lees E; Nakatani Y; Reinberg D (September 1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. (UNITED STATES) 18 (9): 5355–63. ISSN 0270-7306. PMC 109120. PMID 9710619.
↑ Wang, Sheng; Zhang Baohua; Faller Douglas V (June 2002). "Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth". EMBO J. (England) 21 (12): 3019–28. doi:10.1093/emboj/cdf302. ISSN 0261-4189. PMC 126057. PMID 12065415.
↑ Kowenz-Leutz, E; Leutz A (November 1999). "A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes". Mol. Cell (UNITED STATES) 4 (5): 735–43. doi:10.1016/S1097-2765(00)80384-6. ISSN 1097-2765. PMID 10619021.
↑ Inoue, Hiroko; Furukawa Takako; Giannakopoulos Stavros; Zhou Sharleen; King David S; Tanese Naoko (November 2002). "Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors". J. Biol. Chem. (United States) 277 (44): 41674–85. doi:10.1074/jbc.M205961200. ISSN 0021-9258. PMID 12200431.

Aves SJ, Hindley J, Phear GA, Tongue N (1995). "A fission yeast gene mapping close to suc1 encodes a protein containing two bromodomains". Mol. Gen. Genet. 248 (4): 491–8. doi:10.1007/BF02191650. PMID 7565614.
Chiba H, Muramatsu M, Nomoto A, Kato H (1994). "Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor". Nucleic Acids Res. 22 (10): 1815–20. doi:10.1093/nar/22.10.1815. PMC 308079. PMID 8208605.
Muchardt C, Yaniv M (1993). "A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor". EMBO J. 12 (11): 4279–90. PMC 413724. PMID 8223438.
Muchardt C; Reyes JC; Bourachot B et al. (1996). "The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis". EMBO J. 15 (13): 3394–402. PMC 451903. PMID 8670841.
Wang W; Xue Y; Zhou S et al. (1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev. 10 (17): 2117–30. doi:10.1101/gad.10.17.2117. PMID 8804307.
Wang W; Côté J; Xue Y et al. (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. 15 (19): 5370–82. PMC 452280. PMID 8895581.
Ichinose H, Garnier JM, Chambon P, Losson R (1997). "Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2". Gene 188 (1): 95–100. doi:10.1016/S0378-1119(96)00785-8. PMID 9099865.
Cho H; Orphanides G; Sun X et al. (1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. 18 (9): 5355–63. PMC 109120. PMID 9710619.
Thaete C; Brett D; Monaghan P et al. (1999). "Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus". Hum. Mol. Genet. 8 (4): 585–91. doi:10.1093/hmg/8.4.585. PMID 10072425.
Phelan ML, Sif S, Narlikar GJ, Kingston RE (1999). "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits". Mol. Cell 3 (2): 247–53. doi:10.1016/S1097-2765(00)80315-9. PMID 10078207.
Lee DW; Zhang K; Ning ZQ et al. (2000). "Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia". Cancer Res. 60 (13): 3612–22. PMID 10910076.
Phelan ML, Schnitzler GR, Kingston RE (2000). "Octamer Transfer and Creation of Stably Remodeled Nucleosomes by Human SWI-SNF and Its Isolated ATPases". Mol. Cell. Biol. 20 (17): 6380–9. doi:10.1128/MCB.20.17.6380-6389.2000. PMC 86113. PMID 10938115.
Xue Y; Canman JC; Lee CS et al. (2001). "The human SWI/SNF-B chromatin-remodeling complex is related to yeast Rsc and localizes at kinetochores of mitotic chromosomes". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13015–20. doi:10.1073/pnas.240208597. PMC 27170. PMID 11078522.
Machida Y, Murai K, Miyake K, Iijima S (2001). "Expression of chromatin remodeling factors during neural differentiation". J. Biochem. 129 (1): 43–9. doi:10.1093/oxfordjournals.jbchem.a002834. PMID 11134956.
de la Serna IL, Carlson KA, Imbalzano AN (2001). "Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation". Nat. Genet. 27 (2): 187–90. doi:10.1038/84826. PMID 11175787.
Ruhf ML; Braun A; Papoulas O et al. (2001). "The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes". Development 128 (8): 1429–41. PMID 11262242.
Strobeck MW; Reisman DN; Gunawardena RW et al. (2002). "Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling". J. Biol. Chem. 277 (7): 4782–9. doi:10.1074/jbc.M109532200. PMID 11719516.
Kato H; Tjernberg A; Zhang W et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". J. Biol. Chem. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557.
Mizutani T; Ito T; Nishina M et al. (2002). "Maintenance of integrated proviral gene expression requires Brm, a catalytic subunit of SWI/SNF complex". J. Biol. Chem. 277 (18): 15859–64. doi:10.1074/jbc.M112421200. PMID 11850427.

PDB gallery

2dat: Solution structure of the Bromodomain of human SWI/SNF related matrix associated actin dependent regulator of cromatin subfamily A member 2

SMARCA2

Interactions

References

Further reading