SLC9A2
Sodium–hydrogen exchanger 2 is a protein that in humans is encoded by the SLC9A2 gene.[1]
See also
References
Further reading
- Chow CW (1999). "Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3.". Clinical and investigative medicine. Médecine clinique et experimentale 22 (5): 195–206. PMID 10579058.
- Kulanthaivel P, Furesz TC, Moe AJ et al. (1992). "Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na(+)-H+ exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane.". Biochem. J. 284 (1): 33–8. PMC 1132693. PMID 1318024.
- Collins JF, Honda T, Knobel S et al. (1993). "Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2).". Proc. Natl. Acad. Sci. U.S.A. 90 (9): 3938–42. doi:10.1073/pnas.90.9.3938. PMC 46421. PMID 7683411.
- Ghishan FK, Knobel SM, Summar M (1996). "Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2).". Genomics 30 (1): 25–30. doi:10.1006/geno.1995.0004. PMID 8595899.
- Dudeja PK, Rao DD, Syed I et al. (1996). "Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA.". Am. J. Physiol. 271 (3 Pt 1): G483–93. PMID 8843774.
- Lin X, Barber DL (1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange.". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
- "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Chow CW, Woodside M, Demaurex N et al. (1999). "Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia.". J. Biol. Chem. 274 (15): 10481–8. doi:10.1074/jbc.274.15.10481. PMID 10187839.
- Malakooti J, Dahdal RY, Schmidt L et al. (1999). "Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2.". Am. J. Physiol. 277 (2 Pt 1): G383–90. PMID 10444453.
- Malakooti J, Dahdal RY, Dudeja PK et al. (2001). "The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization.". Am. J. Physiol. Gastrointest. Liver Physiol. 280 (4): G763–73. PMID 11254504.
- Pang T, Su X, Wakabayashi S, Shigekawa M (2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers.". J. Biol. Chem. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
- Repishti M, Hogan DL, Pratha V et al. (2001). "Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement.". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G159–63. PMID 11408268.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lacey HA, Nolan T, Greenwood SL et al. (2005). "Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR.". Placenta 26 (1): 93–8. doi:10.1016/j.placenta.2004.05.005. PMID 15664417.
- Hillier LW, Graves TA, Fulton RS et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Pearse I, Zhu YX, Murray EJ et al. (2007). "Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site.". Biochem. J. 407 (1): 101–11. doi:10.1042/BJ20070364. PMC 2267401. PMID 17561809.
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| By group |
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| SLC1–10 |
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| (1): |
- high affinity glutamate and neutral amino-acid transporter
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| (2): | |
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| (3): | |
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| (4): | |
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| (5): | |
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| (8): | |
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| (9): | |
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| (10): | |
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| | SLC11–20 |
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| (11): |
- proton coupled metal ion transporter
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| (12): | |
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| (13): |
- human Na+-sulfate/carboxylate cotransporter
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| (14): | |
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| (15): |
- proton oligopeptide cotransporter
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| (16): |
- monocarboxylate transporter
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| (17): | |
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| (18): | |
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| (19): | |
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| (20): |
- type III Na+-phosphate cotransporter
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| | SLC21–30 |
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| (21): | |
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| (22): |
- organic cation/anion/zwitterion transporter
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| (23): |
- Na+-dependent ascorbic acid transporter
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| (24): | |
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| (25): | |
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| (26): |
- multifunctional anion exchanger
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| (27): | |
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| (28): |
- Na+-coupled nucleoside transport (SLC28A1
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| (29): |
- facilitative nucleoside transporter
- SLC29A1
- SLC29A2
- SLC29A3
- SLC29A4
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| (30): | |
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| | SLC31–40 |
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| (31): | |
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| (32): | |
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| (33): | |
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| (34): |
- type II Na+-phosphate cotransporter
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| (35): |
- nucleoside-sugar transporter
- SLC35A1
- SLC35A2
- SLC35A3
- SLC35A4
- SLC35A5
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-
-
-
- SLC35E1
- SLC35E2
- SLC35E3
- SLC35E4
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| (36): |
- proton-coupled amino-acid transporter
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| (37): |
- sugar-phosphate/phosphate exchanger
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| (38): |
- System A & N, sodium-coupled neutral amino-acid transporter
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| (39): | |
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| (40): |
- basolateral iron transporter
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| | SLC41–48 |
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| (41): | |
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| (42): | |
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| (43): |
- Na+-independent, system-L like amino-acid transporter
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| (44): | |
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| (45): |
- Putative sugar transporter
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| (46): | |
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| | | | see also solute carrier disorders
Index of cells |
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| Description |
- Structure
- Organelles
- peroxisome
- cytoskeleton
- centrosome
- epithelia
- cilia
- mitochondria
- Membranes
- Membrane transport
- ion channels
- vesicular transport
- solute carrier
- ABC transporters
- ATPase
- oxidoreduction-driven
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| Disease |
- Structural
- peroxisome
- cytoskeleton
- cilia
- mitochondria
- nucleus
- scleroprotein
- Membrane
- channelopathy
- solute carrier
- ATPase
- ABC transporters
- other
- extracellular ligands
- cell surface receptors
- intracellular signalling
- Vesicular transport
- Pore-forming toxins
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