SLC6A14
| Solute carrier family 6 (amino acid transporter), member 14 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SLC6A14 ; BMIQ11 | ||||||||||||
| External IDs | OMIM: 300444 MGI: 1890216 HomoloGene: 38290 IUPHAR: 937 GeneCards: SLC6A14 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 11254 | 56774 | |||||||||||
| Ensembl | ENSG00000087916 | ENSMUSG00000031089 | |||||||||||
| UniProt | Q9UN76 | Q9JMA9 | |||||||||||
| RefSeq (mRNA) | NM_007231 | NM_020049 | |||||||||||
| RefSeq (protein) | NP_009162 | NP_064433 | |||||||||||
| Location (UCSC) | Chr HG1463_PATCH: 115.55 – 115.58 Mb | Chr X: 21.71 – 21.74 Mb | |||||||||||
| PubMed search | |||||||||||||
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) is a protein that in humans is encoded by the SLC6A14 gene.[1][2]
Function
SLC6A14 is a member of the Na(+)- and Cl(−)-dependent neurotransmitter transporter family and transports both neutral and cationic amino acids in an Na(+)- and Cl(−)-dependent manner.[supplied by OMIM][2]
References
- ↑ Sloan JL, Mager S (Sep 1999). "Cloning and functional expression of a human Na(+) and Cl(−)-dependent neutral and cationic amino acid transporter B(0+)". J Biol Chem 274 (34): 23740–5. doi:10.1074/jbc.274.34.23740. PMID 10446133.
- ↑ 2.0 2.1 "Entrez Gene: SLC6A14 solute carrier family 6 (amino acid transporter), member 14".
Further reading
- Ohman M, Oksanen L, Kaprio J, Koskenvuo M, Mustajoki P, Rissanen A et al. (2000). "Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24". J. Clin. Endocrinol. Metab. 85 (9): 3183–90. doi:10.1210/jc.85.9.3183. PMID 10999806.
- Sloan JL, Grubb BR, Mager S (2003). "Expression of the amino acid transporter ATB 0+ in lung: possible role in luminal protein removal". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L39–49. doi:10.1152/ajplung.00164.2002 (inactive 2015-01-01). PMID 12388375.
- Suviolahti E, Oksanen LJ, Ohman M, Cantor RM, Ridderstrale M, Tuomi T et al. (2004). "The SLC6A14 gene shows evidence of association with obesity". J. Clin. Invest. 112 (11): 1762–72. doi:10.1172/JCI200317491. PMC 281637. PMID 14660752.
- Durand E, Boutin P, Meyre D, Charles MA, Clement K, Dina C et al. (2004). "Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians". Diabetes 53 (9): 2483–6. doi:10.2337/diabetes.53.9.2483. PMID 15331564.
- Gupta N, Miyauchi S, Martindale RG, Herdman AV, Podolsky R, Miyake K et al. (2005). "Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans". Biochim. Biophys. Acta 1741 (1–2): 215–23. doi:10.1016/j.bbadis.2005.04.002. PMID 15905073.