SLC4A2
| Solute carrier family 4 (anion exchanger), member 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SLC4A2 ; AE2; BND3L; EPB3L1; HKB3; NBND3 | ||||||||||||
| External IDs | OMIM: 109280 MGI: 109351 HomoloGene: 128699 IUPHAR: 905 GeneCards: SLC4A2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6522 | 20535 | |||||||||||
| Ensembl | ENSG00000164889 | ENSMUSG00000028962 | |||||||||||
| UniProt | P04920 | P13808 | |||||||||||
| RefSeq (mRNA) | NM_001199692 | NM_001253892 | |||||||||||
| RefSeq (protein) | NP_001186621 | NP_001240821 | |||||||||||
| Location (UCSC) | Chr 7: 150.75 – 150.77 Mb | Chr 5: 24.42 – 24.44 Mb | |||||||||||
| PubMed search | |||||||||||||
Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene.[1][2] AE2 is functionally similar to the Band 3 Cl−/HCO3− exchange protein.
Mice have been used to explore the function of AE2. AE2 contributes to basolateral membrane HCO3− transport in the gastrointestinal tract.[3] AE2 is required for spermiogenesis in mice.[4] AE2 is required for normal osteoclast function.[5][6] The activity of AE2 is sensitive to pH.[7]
AE3 has been suggested as a target for prevention of diabetic vasculopathy.[8]
See also
References
- ↑ Tanner MJ (Mar 1993). "Molecular and cellular biology of the erythrocyte anion exchanger (AE1)". Semin Hematol 30 (1): 34–57. PMID 8434259.
- ↑ "Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)".
- ↑ Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE (April 2010). "AE2 Cl−/HCO3− exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon". Am. J. Physiol. Gastrointest. Liver Physiol. 298 (4): G493–503. doi:10.1152/ajpgi.00178.2009. PMC 2853300. PMID 20110461.
- ↑ Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, Ottenhoff R, Bosma PJ, Bakker CT, Elferink RP (December 2003). "Anion exchanger 2 is essential for spermiogenesis in mice". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15847–52. doi:10.1073/pnas.2536127100. PMC 307656. PMID 14673081.
- ↑ Wu J, Glimcher LH, Aliprantis AO (November 2008). "HCO3−/Cl− anion exchanger SLC4A2 is required for proper osteoclast differentiation and function". Proc. Natl. Acad. Sci. U.S.A. 105 (44): 16934–9. doi:10.1073/pnas.0808763105. PMC 2579356. PMID 18971331.
- ↑ Josephsen K, Praetorius J, Frische S, Gawenis LR, Kwon TH, Agre P, Nielsen S, Fejerskov O (February 2009). "Targeted disruption of the Cl−/HCO3− exchanger Ae2 results in osteopetrosis in mice". Proc. Natl. Acad. Sci. U.S.A. 106 (5): 1638–41. doi:10.1073/pnas.0811682106. PMC 2635809. PMID 19164575.
- ↑ Stewart AK, Kurschat CE, Vaughan-Jones RD, Alper SL (March 2009). "Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH". J. Biol. Chem. 284 (10): 6126–39. doi:10.1074/jbc.M802051200. PMC 2649077. PMID 19103596.
- ↑ Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M (June 2010). "Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway". Apoptosis 15 (6): 693–704. doi:10.1007/s10495-010-0477-9. PMID 20180022.
Further reading
- Gehrig H, Müller W, Appelhans H (1992). "Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney.". Biochim. Biophys. Acta 1130 (3): 326–8. doi:10.1016/0167-4781(92)90446-7. PMID 1562608.
- Korsgren C, Cohen CM (1988). "Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3.". J. Biol. Chem. 263 (21): 10212–8. PMID 2968981.
- Demuth DR, Showe LC, Ballantine M et al. (1986). "Cloning and structural characterization of a human non-erythroid band 3-like protein.". EMBO J. 5 (6): 1205–14. PMC 1166929. PMID 3015590.
- Palumbo AP, Isobe M, Huebner K et al. (1986). "Chromosomal localization of a human band 3-like gene to region 7q35----7q36.". Am. J. Hum. Genet. 39 (3): 307–16. PMC 1683956. PMID 3020980.
- Rybicki AC, Musto S, Schwartz RS (1995). "Identification of a band-3 binding site near the N-terminus of erythrocyte membrane protein 4.2.". Biochem. J. 309. ( Pt 2): 677–81. PMC 1135783. PMID 7626035.
- Havenga MJ, Bosman GJ, Appelhans H, De Grip WJ (1995). "Expression of the anion exchanger (AE) gene family in human brain. Identification of a new AE protein: AE0.". Brain Res. Mol. Brain Res. 25 (1-2): 97–104. doi:10.1016/0169-328X(94)90283-6. PMID 7984058.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Medina JF, Acín A, Prieto J (1997). "Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) gene.". Genomics 39 (1): 74–85. doi:10.1006/geno.1996.4467. PMID 9027488.
- García C, Montuenga LM, Medina JF, Prieto J (1998). "In situ detection of AE2 anion-exchanger mRNA in the human liver.". Cell Tissue Res. 291 (3): 481–8. doi:10.1007/s004410051017. PMID 9477304.
- Jöns T, Drenckhahn D (1998). "Anion exchanger 2 (AE2) binds to erythrocyte ankyrin and is colocalized with ankyrin along the basolateral plasma membrane of human gastric parietal cells.". Eur. J. Cell Biol. 75 (3): 232–6. doi:10.1016/s0171-9335(98)80117-9. PMID 9587054.
- Mobasheri A, Golding S, Pagakis SN et al. (1999). "Expression of cation exchanger NHE and anion exchanger AE isoforms in primary human bone-derived osteoblasts.". Cell Biol. Int. 22 (7-8): 551–62. doi:10.1006/cbir.1998.0299. PMID 10452823.
- Hyde K, Harrison D, Hollingsworth MA, Harris A (1999). "Chloride-bicarbonate exchangers in the human fetal pancreas.". Biochem. Biophys. Res. Commun. 263 (2): 315–21. doi:10.1006/bbrc.1999.1367. PMID 10491290.
- Holappa K, Mustonen M, Parvinen M et al. (1999). "Primary structure of a sperm cell anion exchanger and its messenger ribonucleic acid expression during spermatogenesis.". Biol. Reprod. 61 (4): 981–6. doi:10.1095/biolreprod61.4.981. PMID 10491633.
- Karet FE, Finberg KE, Nayir A et al. (2000). "Localization of a gene for autosomal recessive distal renal tubular acidosis with normal hearing (rdRTA2) to 7q33-34.". Am. J. Hum. Genet. 65 (6): 1656–65. doi:10.1086/302679. PMC 1288376. PMID 10577919.
- Medina JF, Lecanda J, Acín A et al. (2000). "Tissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene.". Biochem. Biophys. Res. Commun. 267 (1): 228–35. doi:10.1006/bbrc.1999.1951. PMID 10623603.
- Vince JW, Reithmeier RA (2000). "Identification of the Carbonic Anhydrase II Binding Site in the Cl−/HCO3− Anion Exchanger AE1.". Biochemistry 39 (18): 5527–33. doi:10.1021/bi992564p. PMID 10820026.
- Holappa K, Suokas M, Soininen P, Kellokumpu S (2001). "Identification of the full-length AE2 (AE2a) isoform as the Golgi-associated anion exchanger in fibroblasts.". J. Histochem. Cytochem. 49 (2): 259–69. doi:10.1177/002215540104900213. PMID 11156694.
- Soleimani M, Greeley T, Petrovic S et al. (2001). "Pendrin: an apical Cl−/OH−/HCO3− exchanger in the kidney cortex.". Am. J. Physiol. Renal Physiol. 280 (2): F356–64. PMID 11208611.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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