SLC38A1

Solute carrier family 38, member 1

Identifiers

SLC38A1 ; ATA1; NAT2; SAT1; SNAT1

External IDs

OMIM: 608490 MGI: 2145895 HomoloGene: 12745 IUPHAR: 1169 GeneCards: SLC38A1 Gene

Gene ontology
Molecular function	• sodium:amino acid symporter activity • neutral amino acid transmembrane transporter activity • L-glutamine transmembrane transporter activity
Cellular component	• plasma membrane • integral component of membrane • axon • extracellular vesicular exosome
Biological process	• neurotransmitter uptake • amino acid transmembrane transport • ion transport • sodium ion transport • amino acid transport • glutamine transport • synaptic transmission • neutral amino acid transport • transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000111371

ENSMUSG00000023169

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
46.58 – 46.66 Mb

Chr 15:
96.57 – 96.64 Mb

PubMed search

Sodium-coupled neutral amino acid transporter 1 is a protein that in humans is encoded by the SLC38A1 gene.^[1]^[2]

Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001).[supplied by OMIM]^[2]

References

↑ Wang H, Huang W, Sugawara M, Devoe LD, Leibach FH, Prasad PD, Ganapathy V (Sep 2000). "Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta". Biochem Biophys Res Commun 273 (3): 1175–9. doi:10.1006/bbrc.2000.3061. PMID 10891391.
↑ 2.0 2.1 "Entrez Gene: SLC38A1 solute carrier family 38, member 1".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Gu S, Roderick HL, Camacho P, Jiang JX (2001). "Characterization of an N-system amino acid transporter expressed in retina and its involvement in glutamine transport.". J. Biol. Chem. 276 (26): 24137–44. doi:10.1074/jbc.M009003200. PMID 11325958.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Melone M, Quagliano F, Barbaresi P et al. (2004). "Localization of the glutamine transporter SNAT1 in rat cerebral cortex and neighboring structures, with a note on its localization in human cortex.". Cereb. Cortex 14 (5): 562–74. doi:10.1093/cercor/bhh018. PMID 15054072.
Otsuki T, Ota T, Nishikawa T et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Kondoh N, Imazeki N, Arai M et al. (2007). "Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues.". Int. J. Oncol. 31 (1): 81–7. doi:10.3892/ijo.31.1.81. PMID 17549407.