SLC25A5
Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 is a protein that in humans is encoded by the SLC25A5 gene. [1]
Function
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Sep 2009].
References
Further reading
- Bisson, N.; James, D. A.; Ivosev, G.; Tate, S. A.; Bonner, R.; Taylor, L.; Pawson, T. (2011). "Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor". Nature Biotechnology 29 (7): 653–658. doi:10.1038/nbt.1905. PMID 21706016.
- Doerner, A.; Pauschinger, M.; Badorff, A.; Noutsias, M.; Giessen, S.; Schulze, K.; Bilger, J.; Rauch, U.; Schultheiss, H. P. (1997). "Tissue-specific transcription pattern of the adenine nucleotide translocase isoforms in humans". FEBS letters 414 (2): 258–262. doi:10.1016/S0014-5793(97)01000-4. PMID 9315697.
- Vasilescu, J.; Zweitzig, D. R.; Denis, N. J.; Smith, J. C.; Ethier, M.; Haines, D. S.; Figeys, D. (2007). "The Proteomic Reactor Facilitates the Analysis of Affinity-Purified Proteins by Mass Spectrometry: Application for Identifying Ubiquitinated Proteins in Human Cells". Journal of Proteome Research 6 (1): 298–305. doi:10.1021/pr060438j. PMID 17203973.
- Chen, S. T.; Chang, C. D.; Huebner, K.; Ku, D. H.; McFarland, M.; Deriel, J. K.; Baserga, R.; Wurzel, J. (1990). "A human ADP/ATP translocase gene has seven pseudogenes and localizes to chromosome X". Somatic cell and molecular genetics 16 (2): 143–149. doi:10.1007/BF01233044. PMID 2157297.
- Schlattner, U.; Dolder, M.; Wallimann, T.; Tokarska-Schlattner, M. (2001). "Mitochondrial creatine kinase and mitochondrial outer membrane porin show a direct interaction that is modulated by calcium". The Journal of biological chemistry 276 (51): 48027–48030. doi:10.1074/jbc.M106524200. PMID 11602586.
- Schiebel, K.; Mertz, A.; Winkelmann, M.; Nagaraja, R.; Rappold, G. (1994). "Localization of the Adenine Nucleotide Translocase Gene ANT2 to Chromosome Xq24-q25 with Tight Linkage to DXS425". Genomics 24 (3): 605–606. doi:10.1006/geno.1994.1675. PMID 7713517.
- Piwko, W.; Olma, M. H.; Held, M.; Bianco, J. N.; Pedrioli, P. G. A.; Hofmann, K.; Pasero, P.; Gerlich, D. W.; Peter, M. (2010). "RNAi-based screening identifies the Mms22L–Nfkbil2 complex as a novel regulator of DNA replication in human cells". The EMBO Journal 29 (24): 4210–4222. doi:10.1038/emboj.2010.304. PMC 3018799. PMID 21113133.
- Giraud, S. P.; Bonod-Bidaud, C.; Wesolowski-Louvel, M.; Stepien, G. (1998). "Expression of human ANT2 gene in highly proliferative cells: GRBOX, a new transcriptional element, is involved in the regulation of glycolytic ATP import into mitochondria". Journal of Molecular Biology 281 (3): 409–418. doi:10.1006/jmbi.1998.1955. PMID 9698557.
- Chevrollier, A.; Loiseau, D.; Reynier, P.; Stepien, G. (2011). "Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism". Biochimica et Biophysica Acta (BBA) - Bioenergetics 1807 (6): 562–567. doi:10.1016/j.bbabio.2010.10.008. PMID 20950584.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.