SLAMF8

SLAM family member 8

Identifiers

SLAMF8 ; BLAME; CD353; SBBI42

External IDs

OMIM: 606620 MGI: 1921998 HomoloGene: 10589 GeneCards: SLAMF8 Gene

Gene ontology
Molecular function	• receptor activity
Cellular component	• integral component of membrane
Biological process	• regulation of NAD(P)H oxidase activity • cellular response to drug • defense response to bacterium • regulation of kinase activity • phagosome acidification
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000158714

ENSMUSG00000053318

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
159.8 – 159.81 Mb

Chr 1:
172.58 – 172.59 Mb

PubMed search

SLAM family member 8 is a protein that in humans is encoded by the SLAMF8 gene.^[1]^[2]

This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes.^[2]

References

↑ Kingsbury GA, Feeney LA, Nong Y, Calandra SA, Murphy CJ, Corcoran JM, Wang Y, Prabhu Das MR, Busfield SJ, Fraser CC, Villeval JL (Apr 2001). "Cloning, expression, and function of BLAME, a novel member of the CD2 family". J Immunol 166 (9): 5675–80. doi:10.4049/jimmunol.166.9.5675. PMID 11313408.
↑ 2.0 2.1 "Entrez Gene: SLAMF8 SLAM family member 8".

Further reading

Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". J. Immunol. 171 (5): 2485–95. doi:10.4049/jimmunol.171.5.2485. PMID 12928397.
Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T; Ota T; Nishikawa T et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Kimura K; Wakamatsu A; Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gregory SG; Barlow KF; McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.