SHPRH

SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2M85

Identifiers

SHPRH ; bA545I5.2

External IDs

OMIM: 608048 MGI: 1917581 HomoloGene: 6489 GeneCards: SHPRH Gene

Gene ontology
Molecular function	• DNA binding • helicase activity • ubiquitin-protein transferase activity • ATP binding • zinc ion binding • ligase activity
Cellular component	• nucleosome • nucleus
Biological process	• protein polyubiquitination • DNA repair • nucleosome assembly
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000146414

ENSMUSG00000090112

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
146.19 – 146.29 Mb

Chr 10:
11.15 – 11.22 Mb

PubMed search

E3 ubiquitin-protein ligase SHPRH is an enzyme that in humans is encoded by the SHPRH gene.^[1]^[2]

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases.[supplied by OMIM]^[2]

References

↑ Sood R, Makalowska I, Galdzicki M, Hu P, Eddings E, Robbins CM, Moses T, Namkoong J, Chen S, Trent JM (Jul 2003). "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region". Genomics 82 (2): 153–61. doi:10.1016/S0888-7543(03)00121-6. PMID 12837266.
↑ 2.0 2.1 "Entrez Gene: SHPRH SNF2 histone linker PHD RING helicase".

Further reading

Motegi A; Sood R; Moinova H et al. (2007). "Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination". J. Cell Biol. 175 (5): 703–8. doi:10.1083/jcb.200606145. PMC 2064669. PMID 17130289.
Unk I; Hajdú I; Fátyol K et al. (2007). "Human SHPRH is a ubiquitin ligase for Mms2–Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen". Proc. Natl. Acad. Sci. U.S.A. 103 (48): 18107–12. doi:10.1073/pnas.0608595103. PMC 1838714. PMID 17108083.
Stelzl U; Worm U; Lalowski M et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Jin J; Smith FD; Stark C et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Adams MD; Kerlavage AR; Fleischmann RD et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature 377 (6547 Suppl): 3–174. PMID 7566098.