SH3GL3
| SH3-domain GRB2-like 3 | |||||||||||||
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 PDB rendering based on 2ew3. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SH3GL3 ; CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13 | ||||||||||||
| External IDs | OMIM: 603362 MGI: 700011 HomoloGene: 37723 GeneCards: SH3GL3 Gene | ||||||||||||
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| Species | Human | Mouse | |||||||||||
| Entrez | 6457 | 20408 | |||||||||||
| Ensembl | ENSG00000140600 | ENSMUSG00000030638 | |||||||||||
| UniProt | Q99963 | Q62421 | |||||||||||
| RefSeq (mRNA) | NM_001301108 | NM_001277954 | |||||||||||
| RefSeq (protein) | NP_001288037 | NP_001264883 | |||||||||||
| Location (UCSC) | Chr 15: 84.12 – 84.29 Mb | Chr 7: 82.17 – 82.31 Mb | |||||||||||
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Endophilin-A3 is a protein that in humans is encoded by the SH3GL3 gene.[1][2]
Interactions
SH3GL3 has been shown to interact with Huntingtin[3] and SH3KBP1.[4]
References
- ↑ Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (July 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142.
- ↑ "Entrez Gene: SH3GL3 SH3-domain GRB2-like 3".
- ↑ Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H et al. (October 1998). "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates". Mol. Cell 2 (4): 427–36. doi:10.1016/S1097-2765(00)80142-2. PMID 9809064. Vancouver style error (help)
- ↑ Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.
Further reading
- So CW, Caldas C, Liu MM, Chen SJ, Huang QH, Gu LJ et al. (1997). "EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia.". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2563–8. doi:10.1073/pnas.94.6.2563. PMC 20128. PMID 9122235.
- Ringstad N, Nemoto Y, De Camilli P (1997). "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain.". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8569–74. doi:10.1073/pnas.94.16.8569. PMC 23017. PMID 9238017.
- Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H et al. (1998). "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates.". Mol. Cell 2 (4): 427–36. doi:10.1016/S1097-2765(00)80142-2. PMID 9809064. Vancouver style error (help)
- Tang Y, Hu LA, Miller WE, Ringstad N, Hall RA, Pitcher JA et al. (1999). "Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12559–64. doi:10.1073/pnas.96.22.12559. PMC 22990. PMID 10535961.
- Cestra G, Castagnoli L, Dente L, Minenkova O, Petrelli A, Migone N et al. (1999). "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.". J. Biol. Chem. 274 (45): 32001–7. doi:10.1074/jbc.274.45.32001. PMID 10542231.
- So CW, So CK, Cheung N, Chew SL, Sham MH, Chan LC (2000). "The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis.". Leukemia 14 (4): 594–601. doi:10.1038/sj.leu.2401692. PMID 10764144.
- So CW, Sham MH, Chew SL, Cheung N, So CK, Chung SK et al. (2000). "Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins.". Biochem. J. 348 (2): 447–58. doi:10.1042/0264-6021:3480447. PMC 1221085. PMID 10816441.
- Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.". Nature 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.
- Chatellard-Causse C, Blot B, Cristina N, Torch S, Missotten M, Sadoul R (2002). "Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization.". J. Biol. Chem. 277 (32): 29108–15. doi:10.1074/jbc.M204019200. PMID 12034747.
- Verdier F, Valovka T, Zhyvoloup A, Drobot LB, Buchman V, Waterfield M et al. (2002). "Ruk is ubiquitinated but not degraded by the proteasome.". Eur. J. Biochem. 269 (14): 3402–8. doi:10.1046/j.1432-1033.2002.03031.x. PMID 12135478.
- Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I (2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.". J. Biol. Chem. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.
- Otsuki M, Itoh T, Takenawa T (2003). "Neural Wiskott-Aldrich syndrome protein is recruited to rafts and associates with endophilin A in response to epidermal growth factor.". J. Biol. Chem. 278 (8): 6461–9. doi:10.1074/jbc.M207433200. PMID 12477732.
- Yam JW, Jin DY, So CW, Chan LC (2004). "Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein.". Blood 103 (4): 1445–53. doi:10.1182/blood-2003-07-2452. PMID 14551139.
- Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
- Trevaskis J, Walder K, Foletta V, Kerr-Bayles L, McMillan J, Cooper A et al. (2005). "Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance.". Endocrinology 146 (9): 3757–64. doi:10.1210/en.2005-0282. PMID 15919751.
- Ralser M, Nonhoff U, Albrecht M, Lengauer T, Wanker EE, Lehrach H et al. (2005). "Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.". Hum. Mol. Genet. 14 (19): 2893–909. doi:10.1093/hmg/ddi321. PMID 16115810.
- Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. Vancouver style error (help)
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