SH3GL2

SH3-domain GRB2-like 2

PDB rendering based on 1x03.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1X03, 1X04, 2D4C, 2DBM

Identifiers

Symbols

SH3GL2 ; CNSA2; EEN-B1; SH3D2A; SH3P4

External IDs

OMIM: 604465 MGI: 700009 HomoloGene: 20652 GeneCards: SH3GL2 Gene

Gene ontology
Molecular function	• protein binding • lipid binding • identical protein binding
Cellular component	• Golgi membrane • cytosol • plasma membrane • clathrin-coated endocytic vesicle membrane • extracellular vesicular exosome
Biological process	• regulation of receptor internalization • post-Golgi vesicle-mediated transport • signal transduction • epidermal growth factor receptor signaling pathway • axon guidance • central nervous system development • antigen processing and presentation of exogenous peptide antigen via MHC class II • negative regulation of epidermal growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • synaptic vesicle endocytosis • membrane organization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
17.58 – 17.8 Mb

Chr 4:
85.21 – 85.64 Mb

PubMed search

Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.^[1]^[2]

Interactions

SH3GL2 has been shown to interact with DNM1,^[3]^[4] Amphiphysin,^[3]^[4] ADAM9,^[5] SH3KBP1^[6] and ADAM15.^[5]

References

↑ Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (Jul 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142.
↑ "Entrez Gene: SH3GL2 SH3-domain GRB2-like 2".
↑ 3.0 3.1 Micheva, K D; Kay B K; McPherson P S (Oct 1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin". J. Biol. Chem. (UNITED STATES) 272 (43): 27239–45. doi:10.1074/jbc.272.43.27239. ISSN 0021-9258. PMID 9341169.
↑ 4.0 4.1 Modregger, Jan; Schmidt Anne A; Ritter Brigitte; Huttner Wieland B; Plomann Markus (Feb 2003). "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1". J. Biol. Chem. (United States) 278 (6): 4160–7. doi:10.1074/jbc.M208568200. ISSN 0021-9258. PMID 12456676.
↑ 5.0 5.1 Howard, L; Nelson K K; Maciewicz R A; Blobel C P (Oct 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. (UNITED STATES) 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. ISSN 0021-9258. PMID 10531379.
↑ Soubeyran, Philippe; Kowanetz Katarzyna; Szymkiewicz Iwona; Langdon Wallace Y; Dikic Ivan (Mar 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature (England) 416 (6877): 183–7. doi:10.1038/416183a. ISSN 0028-0836. PMID 11894095.

Reutens AT, Begley CG (2002). "Endophilin-1: a multifunctional protein.". Int. J. Biochem. Cell Biol. 34 (10): 1173–7. doi:10.1016/S1357-2725(02)00063-8. PMID 12127567.
So CW, Caldas C, Liu MM et al. (1997). "EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia.". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2563–8. doi:10.1073/pnas.94.6.2563. PMC 20128. PMID 9122235.
Ringstad N, Nemoto Y, De Camilli P (1997). "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain.". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8569–74. doi:10.1073/pnas.94.16.8569. PMC 23017. PMID 9238017.
Micheva KD, Ramjaun AR, Kay BK, McPherson PS (1997). "SH3 domain-dependent interactions of endophilin with amphiphysin.". FEBS Lett. 414 (2): 308–12. doi:10.1016/S0014-5793(97)01016-8. PMID 9315708.
Micheva KD, Kay BK, McPherson PS (1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin.". J. Biol. Chem. 272 (43): 27239–45. doi:10.1074/jbc.272.43.27239. PMID 9341169.
Howard L, Nelson KK, Maciewicz RA, Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.". J. Biol. Chem. 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379.
Tang Y, Hu LA, Miller WE et al. (1999). "Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12559–64. doi:10.1073/pnas.96.22.12559. PMC 22990. PMID 10535961.
Cestra G, Castagnoli L, Dente L et al. (1999). "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.". J. Biol. Chem. 274 (45): 32001–7. doi:10.1074/jbc.274.45.32001. PMID 10542231.
So CW, So CK, Cheung N et al. (2000). "The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis.". Leukemia 14 (4): 594–601. doi:10.1038/sj.leu.2401692. PMID 10764144.
So CW, Sham MH, Chew SL et al. (2000). "Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins.". Biochem. J. 348 (2): 447–58. doi:10.1042/0264-6021:3480447. PMC 1221085. PMID 10816441.
Zucconi A, Dente L, Santonico E et al. (2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1.". J. Mol. Biol. 307 (5): 1329–39. doi:10.1006/jmbi.2001.4572. PMID 11292345.
Ramjaun AR, Angers A, Legendre-Guillemin V et al. (2001). "Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase.". J. Biol. Chem. 276 (31): 28913–9. doi:10.1074/jbc.M103198200. PMID 11384986.
Chen-Hwang MC, Chen HR, Elzinga M, Hwang YW (2002). "Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate.". J. Biol. Chem. 277 (20): 17597–604. doi:10.1074/jbc.M111101200. PMID 11877424.
Soubeyran P, Kowanetz K, Szymkiewicz I et al. (2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.". Nature 416 (6877): 183–7. doi:10.1038/416183a. PMID 11894095.
Petrelli A, Gilestro GF, Lanzardo S et al. (2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.". Nature 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.
Chatellard-Causse C, Blot B, Cristina N et al. (2002). "Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization.". J. Biol. Chem. 277 (32): 29108–15. doi:10.1074/jbc.M204019200. PMID 12034747.
Szymkiewicz I, Kowanetz K, Soubeyran P et al. (2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.". J. Biol. Chem. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.
Haglund K, Shimokawa N, Szymkiewicz I, Dikic I (2002). "Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12191–6. doi:10.1073/pnas.192462299. PMC 129420. PMID 12218189.
Verstreken P, Kjaerulff O, Lloyd TE et al. (2002). "Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release.". Cell 109 (1): 101–12. doi:10.1016/S0092-8674(02)00688-8. PMID 11955450.

PDB gallery

1x03: Crystal structure of endophilin BAR domain

1zww: Crystal structure of endophilin-A1 BAR domain

2c08: RAT ENDOPHILIN A1 BAR DOMAIN

2d4c: Crystal structure of the endophilin BAR domain mutant

2dbm: Solution structures of the SH3 domain of human SH3-containing GRB2-like protein 2

SH3GL2

Interactions

References

Further reading