SH2D2A
| SH2 domain containing 2A | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SH2D2A ; F2771; SCAP; TSAD; VRAP | ||||||||||||
| External IDs | OMIM: 604514 MGI: 1351596 HomoloGene: 2958 GeneCards: SH2D2A Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9047 | 27371 | |||||||||||
| Ensembl | ENSG00000027869 | ENSMUSG00000028071 | |||||||||||
| UniProt | Q9NP31 | Q9QXK9 | |||||||||||
| RefSeq (mRNA) | NM_001161441 | NM_001025571 | |||||||||||
| RefSeq (protein) | NP_001154913 | NP_001020742 | |||||||||||
| Location (UCSC) | Chr 1: 156.78 – 156.79 Mb | Chr 3: 87.85 – 87.86 Mb | |||||||||||
| PubMed search | |||||||||||||
SH2 domain-containing protein 2A is a protein that in humans is encoded by the SH2D2A gene.[1][2]
Interactions
SH2D2A has been shown to interact with MAP3K2.[3]
References
- ↑ Spurkland A, Brinchmann JE, Markussen G, Pedeutour F, Munthe E, Lea T, Vartdal F, Aasheim HC (March 1998). "Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites". J Biol Chem 273 (8): 4539–46. doi:10.1074/jbc.273.8.4539. PMID 9468509.
- ↑ "Entrez Gene: SH2D2A SH2 domain protein 2A".
- ↑ Sun, W; Kesavan K; Schaefer B C; Garrington T P; Ware M; Johnson N L; Gelfand E W; Johnson G L (February 2001). "MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway". J. Biol. Chem. (United States) 276 (7): 5093–100. doi:10.1074/jbc.M003719200. ISSN 0021-9258. PMID 11073940.
Further reading
- Marti F, Lapinski PE, King PD (2005). "The emerging role of the T cell-specific adaptor (TSAd) protein as an autoimmune disease-regulator in mouse and man.". Immunol. Lett. 97 (2): 165–70. doi:10.1016/j.imlet.2004.10.019. PMID 15752554.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Choi YB, Kim CK, Yun Y (1999). "Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation.". J. Immunol. 163 (10): 5242–9. PMID 10553045.
- Rajagopal K, Sommers CL, Decker DC et al. (2000). "RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation.". J. Exp. Med. 190 (11): 1657–68. doi:10.1084/jem.190.11.1657. PMC 2195727. PMID 10587356.
- Wu LW, Mayo LD, Dunbar JD et al. (2000). "VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor.". J. Biol. Chem. 275 (9): 6059–62. doi:10.1074/jbc.275.9.6059. PMID 10692392.
- Dai KZ, Vergnaud G, Ando A et al. (2000). "The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1.". Immunogenetics 51 (3): 179–85. doi:10.1007/s002510050029. PMID 10752626.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Smerdel A, Dai KZ, Lorentzen AR et al. (2005). "Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene.". Genes Immun. 5 (4): 310–2. doi:10.1038/sj.gene.6364093. PMID 15129233.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rush J, Moritz A, Lee KA et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Matsumoto T, Bohman S, Dixelius J et al. (2005). "VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis.". EMBO J. 24 (13): 2342–53. doi:10.1038/sj.emboj.7600709. PMC 1173150. PMID 15962004.
- Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Park D, Park I, Lee D et al. (2007). "The adaptor protein Lad associates with the G protein beta subunit and mediates chemokine-dependent T-cell migration.". Blood 109 (12): 5122–8. doi:10.1182/blood-2005-10-061838. PMID 17327418.