SGSM2

Small G protein signaling modulator 2
Identifiers
SymbolsSGSM2 ; RUTBC1
External IDsOMIM: 611418 MGI: 2144695 HomoloGene: 14780 GeneCards: SGSM2 Gene
Orthologs
SpeciesHumanMouse
Entrez990597761
EnsemblENSG00000141258ENSMUSG00000038351
UniProtO43147Q80U12
RefSeq (mRNA)NM_001098509NM_197943
RefSeq (protein)NP_001091979NP_922934
Location (UCSC)Chr 17:
2.24 – 2.28 Mb
Chr 11:
74.85 – 74.9 Mb
PubMed search

Small G protein signaling modulator 2 is a protein that in humans is encoded by the SGSM2 gene.[1][2]

Clinical relevance

In a recent genome-wide association study, this gene has been associated with fasting glucose traits, type 2 diabetes and obesity.[3]

References

  1. Yang, H; et al (2007). "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.". Genomics 90 (2): 249–260. doi:10.1016/j.ygeno.2007.03.013. PMID 17509819.
  2. "Entrez Gene: small G protein signaling modulator 2".
  3. Strawbridge, RJ; et al (2011-08-26). "Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes.". Diabetes 60 (10): 2624–34. doi:10.2337/db11-0415. PMC 3178302. PMID 21873549.

Further reading