SGK2
Serine/threonine-protein kinase Sgk2 is an enzyme that in humans is encoded by the SGK2 gene.[1][2]
This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Two alternate transcripts encoding two different isoforms have been described.[2]
References
- ↑ Kobayashi T, Deak M, Morrice N, Cohen P (Jan 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". Biochem J. 344 Pt 1: 189–97. doi:10.1042/0264-6021:3440189. PMC 1220630. PMID 10548550.
- ↑ 2.0 2.1 "Entrez Gene: SGK2 serum/glucocorticoid regulated kinase 2".
Further reading
- Lang F, Cohen P (2002). "Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms". Sci. STKE 2001 (108): RE17. doi:10.1126/stke.2001.108.re17. PMID 11707620.
- Deloukas P; Matthews LH; Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Gamper N; Fillon S; Feng Y et al. (2003). "K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK". Pflugers Arch. 445 (1): 60–6. doi:10.1007/s00424-002-0873-2. PMID 12397388.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Friedrich B; Feng Y; Cohen P et al. (2003). "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC". Pflugers Arch. 445 (6): 693–6. doi:10.1007/s00424-002-0993-8. PMID 12632189.
- Embark HM; Böhmer C; Vallon V et al. (2003). "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms". Pflugers Arch. 445 (5): 601–6. doi:10.1007/s00424-002-0982-y. PMID 12634932.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Baltaev R; Strutz-Seebohm N; Korniychuk G et al. (2005). "Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes". Pflugers Arch. 450 (1): 26–33. doi:10.1007/s00424-004-1369-z. PMID 15578212.
- Cheng J; Kapranov P; Drenkow J et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807.
External links
- SGK2 human gene location in the UCSC Genome Browser.
- SGK2 human gene details in the UCSC Genome Browser.
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