SFRS7

Serine/arginine-rich splicing factor 7

PDB rendering based on 2hvz.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2HVZ

Identifiers

Symbols

SRSF7 ; 9G8; AAG3; SFRS7

External IDs

OMIM: 600572 MGI: 1926232 HomoloGene: 134446 GeneCards: SRSF7 Gene

Gene ontology
Molecular function	• nucleotide binding • protein binding • zinc ion binding • poly(A) RNA binding
Cellular component	• nucleus • nucleoplasm • nucleolus • cytoplasm • extracellular vesicular exosome
Biological process	• mRNA splicing, via spliceosome • transcription from RNA polymerase II promoter • termination of RNA polymerase II transcription • mRNA processing • mRNA export from nucleus • RNA splicing • gene expression • mRNA 3'-end processing • negative regulation of mRNA splicing, via spliceosome
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
38.97 – 38.98 Mb

Chr 17:
80.2 – 80.21 Mb

PubMed search

Serine/arginine-rich splicing factor 7 (SRSF7) also known as splicing factor, arginine/serine-rich 7 (SFRS7) or splicing factor 9G8 is a protein that in humans is encoded by the SRSF7 gene.^[1]

Function

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation.^[1]

References

↑ 1.0 1.1 "Entrez Gene: SFRS7 splicing factor, arginine/serine-rich 7, 35kDa".

Popielarz M; Cavaloc Y; Mattei MG et al. (1995). "The gene encoding human splicing factor 9G8. Structure, chromosomal localization, and expression of alternatively processed transcripts". J. Biol. Chem. 270 (30): 17830–5. doi:10.1074/jbc.270.30.17830. PMID 7629084.
Cavaloc Y; Popielarz M; Fuchs JP et al. (1994). "Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family". EMBO J. 13 (11): 2639–49. PMC 395138. PMID 8013463.
Yuan Y, Li DM, Sun H (1998). "PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes". J. Biol. Chem. 273 (32): 20347–53. doi:10.1074/jbc.273.32.20347. PMID 9685386.
Lejeune F, Cavaloc Y, Stevenin J (2001). "Alternative splicing of intron 3 of the serine/arginine-rich protein 9G8 gene. Identification of flanking exonic splicing enhancers and involvement of 9G8 as a trans-acting factor". J. Biol. Chem. 276 (11): 7850–8. doi:10.1074/jbc.M009510200. PMID 11096110.
Nogues G; Kadener S; Cramer P et al. (2003). "Transcriptional activators differ in their abilities to control alternative splicing". J. Biol. Chem. 277 (45): 43110–4. doi:10.1074/jbc.M208418200. PMID 12221105.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hu D; Mayeda A; Trembley JH et al. (2003). "CDK11 complexes promote pre-mRNA splicing". J. Biol. Chem. 278 (10): 8623–9. doi:10.1074/jbc.M210057200. PMID 12501247.
Li J; Hawkins IC; Harvey CD et al. (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Yang L; Li N; Wang C et al. (2004). "Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells". J. Biol. Chem. 279 (12): 11639–48. doi:10.1074/jbc.M312895200. PMID 14684736.
Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ropers D; Ayadi L; Gattoni R et al. (2004). "Differential effects of the SR proteins 9G8, SC35, ASF/SF2, and SRp40 on the utilization of the A1 to A5 splicing sites of HIV-1 RNA". J. Biol. Chem. 279 (29): 29963–73. doi:10.1074/jbc.M404452200. PMID 15123677.
Will CL; Schneider C; Hossbach M et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
Dettwiler S; Aringhieri C; Cardinale S et al. (2005). "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization". J. Biol. Chem. 279 (34): 35788–97. doi:10.1074/jbc.M403927200. PMID 15169763.
Lai MC, Tarn WY (2004). "Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteins". J. Biol. Chem. 279 (30): 31745–9. doi:10.1074/jbc.C400173200. PMID 15184380.
Huang Y, Yario TA, Steitz JA (2004). "A molecular link between SR protein dephosphorylation and mRNA export". Proc. Natl. Acad. Sci. U.S.A. 101 (26): 9666–70. doi:10.1073/pnas.0403533101. PMC 470732. PMID 15210956.
Beausoleil SA; Jedrychowski M; Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Jacquenet S, Decimo D, Muriaux D, Darlix JL (2006). "Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production". Retrovirology 2: 33. doi:10.1186/1742-4690-2-33. PMC 1180853. PMID 15907217.
Daan van Abel, Dennis R. Hölzel, Shushant Jain, Fiona M. F. Lun, Yama W. L. Zheng3, Eric Z. Chen, Hao Sun, Rossa W. K. Chiu, Y. M. Dennis Lo, Marie van Dijk, Cees B. M. Oudejans (2011). "SFRS7-Mediated Splicing of Tau Exon 10 Is Directly Regulated by STOX1A in Glial Cells". PLoS ONE 6 (7): e21994. doi:10.1371/journal.pone.0021994. PMC 3130792. PMID 21755018.

PDB gallery

2hvz: Solution structure of the RRM domain of SR rich factor 9G8

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

SFRS7

Function

References

Further reading