SFRS3

Serine/arginine-rich splicing factor 3

Rendering based on PDB 2I2Y.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2I2Y, 2I38

Identifiers

SRSF3 ; SFRS3; SRp20

External IDs

OMIM: 603364 MGI: 98285 HomoloGene: 55708 GeneCards: SRSF3 Gene

Gene ontology
Molecular function	• nucleotide binding • RNA binding • protein binding • poly(A) RNA binding
Cellular component	• nucleoplasm • cytoplasm
Biological process	• mRNA splicing, via spliceosome • transcription from RNA polymerase II promoter • termination of RNA polymerase II transcription • mRNA export from nucleus • RNA splicing • gene expression • mRNA 3'-end processing
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000112081

ENSMUSG00000071172

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
36.56 – 36.57 Mb

Chr 17:
29.03 – 29.04 Mb

PubMed search

Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.^[1]^[2]

Browser View

UCSC Genome Browser View

UCSC Gene details page

Interactions

SFRS3 has been shown to interact with RBM7.^[3]

References

↑ Zahler AM, Lane WS, Stolk JA, Roth MB (Jun 1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev 6 (5): 837–47. doi:10.1101/gad.6.5.837. PMID 1577277.
↑ "Entrez Gene: SFRS3 splicing factor, arginine/serine-rich 3".
↑ Guo, Taylor B; Boros Laszlo G; Chan Kam C; Hikim Amiya P Sinha; Hudson Alan P; Swerdloff Ronald S; Mitchell Aaron P; Salameh Wael A (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". J. Androl. (United States) 24 (2): 204–14. ISSN 0196-3635. PMID 12634307.

Further reading

Ayane M, Preuss U, Köhler G, Nielsen PJ (1991). "A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs.". Nucleic Acids Res. 19 (6): 1273–8. doi:10.1093/nar/19.6.1273. PMC 333853. PMID 2030943.
Gui JF, Lane WS, Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle.". Nature 369 (6482): 678–82. doi:10.1038/369678a0. PMID 8208298.
Cáceres JF, Screaton GR, Krainer AR (1998). "A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm.". Genes Dev. 12 (1): 55–66. doi:10.1101/gad.12.1.55. PMC 316398. PMID 9420331.
Zhang WJ, Wu JY (1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing.". Mol. Cell. Biol. 18 (2): 676–84. PMC 108778. PMID 9447963.
Tripodis N, Mason R, Humphray SJ et al. (1999). "Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex.". Genome Res. 8 (6): 631–43. doi:10.1101/gr.8.6.631. PMC 310739. PMID 9647638.
Papoutsopoulou S, Nikolakaki E, Chalepakis G et al. (1999). "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1.". Nucleic Acids Res. 27 (14): 2972–80. doi:10.1093/nar/27.14.2972. PMC 148514. PMID 10390541.
Barnard DC, Patton JG (2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.". Mol. Cell. Biol. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC 85584. PMID 10757789.
Shnyreva M, Schullery DS, Suzuki H et al. (2000). "Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein.". J. Biol. Chem. 275 (20): 15498–503. doi:10.1074/jbc.275.20.15498. PMID 10809782.
Elliott DJ, Bourgeois CF, Klink A et al. (2000). "A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection.". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 5717–22. doi:10.1073/pnas.97.11.5717. PMC 18499. PMID 10823932.
Huang Y, Steitz JA (2001). "Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA.". Mol. Cell 7 (4): 899–905. doi:10.1016/S1097-2765(01)00233-7. PMID 11336712.
Andersen JS, Lyon CE, Fox AH et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Barnard DC, Li J, Peng R, Patton JG (2002). "Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins.". RNA 8 (4): 526–33. doi:10.1017/S1355838202029928. PMC 1370273. PMID 11991645.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Guo TB, Boros LG, Chan KC et al. (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors.". J. Androl. 24 (2): 204–14. PMID 12634307.
Tai HH, Geisterfer M, Bell JC et al. (2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins.". Biochem. Biophys. Res. Commun. 308 (1): 170–6. doi:10.1016/S0006-291X(03)01354-8. PMID 12890497.
Li J, Hawkins IC, Harvey CD et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins.". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dettwiler S, Aringhieri C, Cardinale S et al. (2005). "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization.". J. Biol. Chem. 279 (34): 35788–97. doi:10.1074/jbc.M403927200. PMID 15169763.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.