SFRS12

Splicing regulatory glutamine/lysine-rich protein 1

Identifiers

SREK1 ; SFRS12; SRrp508; SRrp86

External IDs

OMIM: 609268 MGI: 2145245 HomoloGene: 10581 GeneCards: SREK1 Gene

Gene ontology
Molecular function	• nucleotide binding • poly(A) RNA binding
Cellular component	• nucleus • spliceosomal complex • nucleolus • mitochondrion • intracellular membrane-bounded organelle
Biological process	• mRNA processing • RNA splicing
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000153914

ENSMUSG00000032621

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
65.44 – 65.48 Mb

Chr 13:
103.74 – 103.76 Mb

PubMed search

Splicing factor, arginine/serine-rich 12 is a protein that in humans is encoded by the SFRS12 gene.^[1]^[2]

SFRS12 belongs to the superfamily of serine/arginine-rich (SR) splicing factors. It modulates splice site selection by regulating the activities of other SR proteins (Barnard et al., 2002).[supplied by OMIM]^[2]

References

↑ Zhang DL, Sun XJ, Ling LJ, Chen RS, Ma DL (Jun 2002). "[Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86]". Yi Chuan Xue Bao 29 (5): 377–83. PMID 12043562.
↑ 2.0 2.1 "Entrez Gene: SFRS12 splicing factor, arginine/serine-rich 12".

Further reading

Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Heese K, Fujita M, Akatsu H et al. (2005). "The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain.". J. Mol. Neurosci. 24 (2): 269–76. doi:10.1385/JMN:24:2:269. PMID 15456940.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Li J, Hawkins IC, Harvey CD et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins.". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Peng R, Dye BT, Pérez I et al. (2002). "PSF and p54nrb bind a conserved stem in U5 snRNA.". RNA 8 (10): 1334–47. doi:10.1017/S1355838202022070. PMC 1370341. PMID 12403470.
Li J, Barnard DC, Patton JG (2002). "A unique glutamic acid-lysine (EK) domain acts as a splicing inhibitor.". J. Biol. Chem. 277 (42): 39485–92. doi:10.1074/jbc.M201784200. PMID 12183448.
Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome.". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC 186633. PMID 12176931.
Barnard DC, Li J, Peng R, Patton JG (2002). "Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins.". RNA 8 (4): 526–33. doi:10.1017/S1355838202029928. PMC 1370273. PMID 11991645.
Barnard DC, Patton JG (2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.". Mol. Cell. Biol. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC 85584. PMID 10757789.