SFRS11
| Serine/arginine-rich splicing factor 11 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SRSF11 ; NET2; SFRS11; dJ677H15.2; p54 | ||||||||||||
| External IDs | OMIM: 602010 MGI: 1916457 HomoloGene: 36164 GeneCards: SRSF11 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9295 | 69207 | |||||||||||
| Ensembl | ENSG00000116754 | ENSMUSG00000055436 | |||||||||||
| UniProt | Q05519 | E9Q6E5 | |||||||||||
| RefSeq (mRNA) | NM_001190987 | NM_001093752 | |||||||||||
| RefSeq (protein) | NP_001177916 | NP_001087221 | |||||||||||
| Location (UCSC) | Chr 1: 70.67 – 70.72 Mb | Chr 3: 158.01 – 158.04 Mb | |||||||||||
| PubMed search | |||||||||||||
Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.[1][2]
This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing.[2]
Interactions
SFRS11 has been shown to interact with U2AF2.[3]
References
- ↑ Chaudhary N, McMahon C, Blobel G (October 1991). "Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components". Proc Natl Acad Sci U S A 88 (18): 8189–93. doi:10.1073/pnas.88.18.8189. PMC 52472. PMID 1896467.
- ↑ 2.0 2.1 "Entrez Gene: SFRS11 splicing factor, arginine/serine-rich 11".
- ↑ Zhang, W J; Wu J Y (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. (UNITED STATES) 16 (10): 5400–8. ISSN 0270-7306. PMC 231539. PMID 8816452.
Further reading
- Zhang WJ, Wu JY (1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. 16 (10): 5400–8. PMC 231539. PMID 8816452.
- Straub T, Grue P, Uhse A et al. (1998). "The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction". J. Biol. Chem. 273 (41): 26261–4. doi:10.1074/jbc.273.41.26261. PMID 9756848.
- Page-McCaw PS, Amonlirdviman K, Sharp PA (2000). "PUF60: a novel U2AF65-related splicing activity". RNA 5 (12): 1548–60. doi:10.1017/S1355838299991938. PMC 1369877. PMID 10606266.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Sakashita E, Tatsumi S, Werner D et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo". Mol. Cell. Biol. 24 (3): 1174–87. doi:10.1128/MCB.24.3.1174-1187.2004. PMC 321435. PMID 14729963.
- Wu JY, Kar A, Kuo D et al. (2006). "SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy". Mol. Cell. Biol. 26 (18): 6739–47. doi:10.1128/MCB.00739-06. PMC 1592875. PMID 16943417.
- Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.