SFPQ

Splicing factor proline/glutamine-rich

Identifiers

SFPQ ; POMP100; PPP1R140; PSF

External IDs

OMIM: 605199 MGI: 1918764 HomoloGene: 3714 GeneCards: SFPQ Gene

Gene ontology
Molecular function	• nucleotide binding • transcription regulatory region sequence-specific DNA binding • core promoter binding • protein binding • poly(A) RNA binding
Cellular component	• nucleus • nucleoplasm • cytoplasm • nuclear matrix • paraspeckles
Biological process	• negative regulation of transcription from RNA polymerase II promoter • alternative mRNA splicing, via spliceosome • DNA repair • DNA recombination • transcription, DNA-templated • mRNA processing • RNA splicing • regulation of circadian rhythm • negative regulation of circadian rhythm • negative regulation of transcription, DNA-templated • rhythmic process • histone H3 deacetylation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
35.64 – 35.66 Mb

Chr 4:
127.02 – 127.04 Mb

PubMed search

Splicing factor, proline- and glutamine-rich is a protein that in humans is encoded by the SFPQ gene.^[1]^[2]

Interactions

SFPQ has been shown to interact with PTBP1,^[1]^[3] NONO,^[4] CDC5L^[5] and Ubiquitin C.^[6]

References

↑ 1.0 1.1 Patton JG, Porro EB, Galceran J, Tempst P, Nadal-Ginard B (April 1993). "Cloning and characterization of PSF, a novel pre-mRNA splicing factor". Genes Dev 7 (3): 393–406. doi:10.1101/gad.7.3.393. PMID 8449401.
↑ "Entrez Gene: SFPQ splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)".
↑ Meissner, M; Dechat T; Gerner C; Grimm R; Foisner R; Sauermann G (January 2000). "Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB". J. Cell. Biochem. (UNITED STATES) 76 (4): 559–66. doi:10.1002/(SICI)1097-4644(20000315)76:4<559::AID-JCB4>3.0.CO;2-U. ISSN 0730-2312. PMID 10653975.
↑ Peng, Rui; Dye Billy T; Pérez Ismael; Barnard Daron C; Thompson Amanda B; Patton James G (October 2002). "PSF and p54nrb bind a conserved stem in U5 snRNA". RNA (United States) 8 (10): 1334–47. doi:10.1017/S1355838202022070. ISSN 1355-8382. PMC 1370341. PMID 12403470.
↑ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.
↑ Stelzl, Ulrich; Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell (United States) 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. ISSN 0092-8674. PMID 16169070.

Shav-Tal Y, Zipori D (2002). "PSF and p54(nrb)/NonO--multi-functional nuclear proteins.". FEBS Lett. 531 (2): 109–14. doi:10.1016/S0014-5793(02)03447-6. PMID 12417296.
Gower HJ, Moore SE, Dickson G et al. (1990). "Cloning and characterization of a myoblast cell surface antigen defined by 24.1D5 monoclonal antibody.". Development 105 (4): 723–31. PMID 2480877.
Gozani O, Patton JG, Reed R (1994). "A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction.". EMBO J. 13 (14): 3356–67. PMC 395233. PMID 8045264.
Zhang WW, Zhang LX, Busch RK et al. (1993). "Purification and characterization of a DNA-binding heterodimer of 52 and 100 kDa from HeLa cells.". Biochem. J. 290 (1): 267–72. PMC 1132410. PMID 8439294.
Clark J, Lu YJ, Sidhar SK et al. (1997). "Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma.". Oncogene 15 (18): 2233–9. doi:10.1038/sj.onc.1201394. PMID 9393982.
Teigelkamp S, Mundt C, Achsel T et al. (1998). "The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p.". RNA 3 (11): 1313–26. PMC 1369570. PMID 9409622.
Straub T, Grue P, Uhse A et al. (1998). "The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction.". J. Biol. Chem. 273 (41): 26261–4. doi:10.1074/jbc.273.41.26261. PMID 9756848.
Lutz CS, Cooke C, O'Connor JP et al. (1998). "The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor.". RNA 4 (12): 1493–9. doi:10.1017/S1355838298981183. PMC 1369720. PMID 9848648.
Meissner M, Dechat T, Gerner C et al. (2000). "Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB.". J. Cell. Biochem. 76 (4): 559–66. doi:10.1002/(SICI)1097-4644(20000315)76:4<559::AID-JCB4>3.0.CO;2-U. PMID 10653975.
Urban RJ, Bodenburg Y, Kurosky A et al. (2000). "Polypyrimidine tract-binding protein-associated splicing factor is a negative regulator of transcriptional activity of the porcine p450scc insulin-like growth factor response element.". Mol. Endocrinol. 14 (6): 774–82. doi:10.1210/me.14.6.774. PMID 10847580.
Straub T, Knudsen BR, Boege F (2000). "PSF/p54(nrb) stimulates "jumping" of DNA topoisomerase I between separate DNA helices.". Biochemistry 39 (25): 7552–8. doi:10.1021/bi992898e. PMID 10858305.
Akhmedov AT, Lopez BS (2000). "Human 100-kDa homologous DNA-pairing protein is the splicing factor PSF and promotes DNA strand invasion.". Nucleic Acids Res. 28 (16): 3022–30. doi:10.1093/nar/28.16.3022. PMC 108454. PMID 10931916.
de Vries H, Rüegsegger U, Hübner W et al. (2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors.". EMBO J. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMC 305781. PMID 11060040.
Dye BT, Patton JG (2001). "An RNA recognition motif (RRM) is required for the localization of PTB-associated splicing factor (PSF) to subnuclear speckles.". Exp. Cell Res. 263 (1): 131–44. doi:10.1006/excr.2000.5097. PMID 11161712.
Mathur M, Tucker PW, Samuels HH (2001). "PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.". Mol. Cell. Biol. 21 (7): 2298–311. doi:10.1128/MCB.21.7.2298-2311.2001. PMC 86864. PMID 11259580.
Shav-Tal Y, Cohen M, Lapter S et al. (2002). "Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions.". Mol. Biol. Cell 12 (8): 2328–40. doi:10.1091/mbc.12.8.2328. PMC 58597. PMID 11514619.
Zhang Z, Carmichael GG (2001). "The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs.". Cell 106 (4): 465–75. doi:10.1016/S0092-8674(01)00466-4. PMID 11525732.
Andersen JS, Lyon CE, Fox AH et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Sewer MB, Nguyen VQ, Huang CJ et al. (2002). "Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription.". Endocrinology 143 (4): 1280–90. doi:10.1210/en.143.4.1280. PMID 11897684.

SFPQ

Interactions

References

Further reading