SEZ6L

Seizure related 6 homolog (mouse)-like

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2YRA

Identifiers

External IDs

OMIM: 607021 HomoloGene: 10895 GeneCards: SEZ6L Gene

Gene ontology
Cellular component	• endoplasmic reticulum membrane • integral component of membrane • neuronal cell body
Biological process	• adult locomotory behavior • cerebellar Purkinje cell layer development • synapse maturation • regulation of protein kinase C signaling
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000100095

ENSMUSG00000058153

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 22:
26.57 – 26.78 Mb

Chr 5:
112.42 – 112.58 Mb

PubMed search

Seizure 6-like protein is a protein that in humans is encoded by the SEZ6L gene.^[1]

References

↑ "Entrez Gene: SEZ6L seizure related 6 homolog (mouse)-like".

Further reading

Gorlov IP, Meyer P, Liloglou T et al. (2007). "Seizure 6-like (SEZ6L) gene and risk for lung cancer.". Cancer Res. 67 (17): 8406–11. doi:10.1158/0008-5472.CAN-06-4784. PMID 17804757.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Collins JE, Wright CL, Edwards CA et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Clark HF, Gurney AL, Abaya E et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Collins JE, Goward ME, Cole CG et al. (2003). "Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
Suzuki H, Gabrielson E, Chen W et al. (2002). "A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer". Nat. Genet. 31 (2): 141–9. doi:10.1038/ng892. PMID 11992124.
Nishioka M, Kohno T, Takahashi M et al. (2001). "Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in a lung cancer cell line". Oncogene 19 (54): 6251–60. doi:10.1038/sj.onc.1204031. PMID 11175339.
Dunham I, Shimizu N, Roe BA et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Nagase T, Ishikawa K, Suyama M et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.