SERPINA9

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
Identifiers
SymbolsSERPINA9 ; GCET1; SERPINA11; SERPINA11b
External IDsMGI: 1919157 HomoloGene: 23633 GeneCards: SERPINA9 Gene
Orthologs
SpeciesHumanMouse
Entrez32765771907
EnsemblENSG00000170054ENSMUSG00000058260
UniProtQ86WD7Q9D7D2
RefSeq (mRNA)NM_001042518NM_027997
RefSeq (protein)NP_001035983NP_082273
Location (UCSC)Chr 14:
94.93 – 94.95 Mb
Chr 12:
103.99 – 104.01 Mb
PubMed search

Serpin A9 also known as centerin or GCET1 is a protein that in humans is encoded by the SERPINA9 gene located on chromosome 14q32.1.[1] Serpin A9 is a member of the serpin family of serine protease inhibitors.

Function

The expression of SERPINA9 is restricted to germinal center B cells and lymphoid malignancies. SERPINA9 is likely to function in vivo in the germinal center as an efficient inhibitor of trypsin-like proteases.[2][3][4]

References

  1. ↑ "Entrez Gene: SERPINA9".
  2. ↑ Paterson MA, Horvath AJ, Pike RN, Coughlin PB (August 2007). "Molecular characterization of centerin, a germinal centre cell serpin". Biochem. J. 405 (3): 489–94. doi:10.1042/BJ20070174. PMC 2267310. PMID 17447896.
  3. ↑ Montes-Moreno S, Roncador G, Maestre L, MartΓ­nez N, Sanchez-Verde L, Camacho FI, Cannata J, Martinez-Torrecuadrada JL, Shen Y, Chan WC, Piris MA (January 2008). "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas". Blood 111 (1): 351–8. doi:10.1182/blood-2007-06-094151. PMID 17898315.
  4. ↑ Paterson MA, Hosking PS, Coughlin PB (July 2008). "Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas". Am. J. Clin. Pathol. 130 (1): 117–26. doi:10.1309/9QKE68QU7B825A3U. PMID 18550480.

Further reading

External links