SEPT8
| Septin 8 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SEPT8 ; SEP2 | ||||||||||||
| External IDs | OMIM: 608418 HomoloGene: 57205 GeneCards: SEPT8 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 23176 | 20362 | |||||||||||
| Ensembl | ENSG00000164402 | ENSMUSG00000018398 | |||||||||||
| UniProt | Q92599 | Q8CHH9 | |||||||||||
| RefSeq (mRNA) | NM_001098811 | NM_001252332 | |||||||||||
| RefSeq (protein) | NP_001092281 | NP_001239261 | |||||||||||
| Location (UCSC) | Chr 5: 132.09 – 132.14 Mb | Chr 11: 53.52 – 53.55 Mb | |||||||||||
| PubMed search | |||||||||||||
Septin-8 is a protein that in humans is encoded by the SEPT8 gene.[1][2][3]
Function
SEPT8 is a member of the highly conserved septin family. Septins are 40- to 60-kD GTPases that assemble as filamentous scaffolds. They are involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking.[3]
Interactions
SEPT8 has been shown to interact with PFTK1[4] and SEPT5.[5][6]
References
- ↑ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
- ↑ Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM (Aug 1997). "Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region". Genome Res 7 (5): 495–512. doi:10.1101/gr.7.5.495. PMID 9149945.
- ↑ 3.0 3.1 "Entrez Gene: SEPT8 septin 8".
- ↑ Yang T, Gao YK, Chen JY (Jul 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34 (4): 520–5. PMID 12098780.
- ↑ Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B (Jul 2003). "Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)". Gene 312: 313–20. doi:10.1016/S0378-1119(03)00635-8. PMID 12909369.
- ↑ Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B (May 2002). "Human septin-septin interaction: CDCrel-1 partners with KIAA0202". FEBS Lett. 519 (1-3): 169–72. doi:10.1016/S0014-5793(02)02749-7. PMID 12023038.
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Wenderfer SE, Slack JP, McCluskey TS, Monaco JJ (2000). "Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11". Genomics 63 (3): 354–73. doi:10.1006/geno.1999.6100. PMID 10704283.
- Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B (2002). "Human septin-septin interaction: CDCrel-1 partners with KIAA0202". FEBS Lett. 519 (1–3): 169–72. doi:10.1016/S0014-5793(02)02749-7. PMID 12023038.
- Yang T, Gao YK, Chen JY (2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34 (4): 520–5. PMID 12098780.
- Macara IG, Baldarelli R, Field CM, Glotzer M, Hayashi Y, Hsu SC, Kennedy MB, Kinoshita M, Longtine M, Low C, Maltais LJ, McKenzie L, Mitchison TJ, Nishikawa T, Noda M, Petty EM, Peifer M, Pringle JR, Robinson PJ, Roth D, Russell SE, Stuhlmann H, Tanaka M, Tanaka T, Trimble WS, Ware J, Zeleznik-Le NJ, Zieger B (2003). "Mammalian septins nomenclature". Mol. Biol. Cell 13 (12): 4111–3. doi:10.1091/mbc.E02-07-0438. PMC 138619. PMID 12475938.
- Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B (2003). "Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)". Gene 312: 313–20. doi:10.1016/S0378-1119(03)00635-8. PMID 12909369.
- Bläser S, Horn J, Würmell P, Bauer H, Strümpell S, Nurden P, Pagenstecher A, Busse A, Wunderle D, Hainmann I, Zieger B (2004). "The novel human platelet septin SEPT8 is an interaction partner of SEPT4". Thromb. Haemost. 91 (5): 959–66. doi:10.1267/THRO04050959. PMID 15116257.
- Martínez C, Sanjuan MA, Dent JA, Karlsson L, Ware J (2005). "Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol". Biochem. J. 382 (Pt 3): 783–91. doi:10.1042/BJ20040372. PMC 1133953. PMID 15214843.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Bläser S, Röseler S, Rempp H, Bartsch I, Bauer H, Lieber M, Lessmann E, Weingarten L, Busse A, Huber M, Zieger B (2006). "Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5". J. Pathol. 210 (1): 103–10. doi:10.1002/path.2013. PMID 16767699.
- Xin X, Pache M, Zieger B, Bartsch I, Prünte C, Flammer J, Meyer P (2007). "Septin expression in proliferative retinal membranes". J. Histochem. Cytochem. 55 (11): 1089–94. doi:10.1369/jhc.7A7188.2007. PMID 17625225.