SEC24A

SEC24 family, member A (S. cerevisiae) is a protein that in humans is encoded by the SEC24A gene.[1] The protein belongs to a protein family that are homologous to yeast Sec24.[2] It is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum.[1]

Model organisms

Model organisms have been used in the study of SEC24A function. A conditional knockout mouse line, called Sec24atm1a(KOMP)Wtsi[8][9] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[10][11][12]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[6][13] Twenty five tests were carried out on mutant mice and one significant abnormality was observed.[6] Male homozygotes had decreased circulating cholesterol and LDL cholesterol levels.[6]

References

  1. ↑ 1.0 1.1 "SEC24 family, member A (S. cerevisiae)". Retrieved 2011-12-05.
  2. ↑ Tang, B. L.; Kausalya, J.; Low, D. Y. H.; Lock, M. L.; Hong, W. (1999). "A Family of Mammalian Proteins Homologous to Yeast Sec24p". Biochemical and Biophysical Research Communications 258 (3): 679–684. doi:10.1006/bbrc.1999.0574. PMID 10329445.
  3. ↑ "Clinical chemistry data for Sec24a". Wellcome Trust Sanger Institute.
  4. ↑ "Salmonella infection data for Sec24a". Wellcome Trust Sanger Institute.
  5. ↑ "Citrobacter infection data for Sec24a". Wellcome Trust Sanger Institute.
  6. ↑ 6.0 6.1 6.2 6.3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  7. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  8. ↑ "International Knockout Mouse Consortium".
  9. ↑ "Mouse Genome Informatics".
  10. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  11. ↑ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  12. ↑ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  13. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading