SCG2

Secretogranin II

Identifiers

SCG2 ; CHGC; EM66; SN; SgII

External IDs

OMIM: 118930 MGI: 103033 HomoloGene: 2591 GeneCards: SCG2 Gene

Gene ontology
Molecular function	• cytokine activity • chemoattractant activity
Cellular component	• extracellular space • secretory granule
Biological process	• MAPK cascade • angiogenesis • negative regulation of endothelial cell proliferation • positive regulation of endothelial cell proliferation • cellular component movement • inflammatory response • protein secretion • intracellular signal transduction • negative regulation of apoptotic process • endothelial cell migration • eosinophil chemotaxis • positive chemotaxis • induction of positive chemotaxis
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000171951

ENSMUSG00000050711

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
224.46 – 224.47 Mb

Chr 1:
79.43 – 79.44 Mb

PubMed search

SCG2, also called secretogranin II (chromogranin C), is a protein which in humans is encoded by the SCG2 gene.^[1]

Function

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown.^[2]

See also

Chromogranin

Further reading

Kirchmair R, Gander R, Egger M et al. (2004). "The neuropeptide secretoneurin acts as a direct angiogenic cytokine in vitro and in vivo.". Circulation 109 (6): 777–83. doi:10.1161/01.CIR.0000112574.07422.C1. PMID 14970115.
Ozawa H, Takata K (1995). "The granin family--its role in sorting and secretory granule formation.". Cell Struct. Funct. 20 (6): 415–20. doi:10.1247/csf.20.415. PMID 8825061.
Huttner WB, Gerdes HH, Rosa P (1991). "The granin (chromogranin/secretogranin) family.". Trends Biochem. Sci. 16 (1): 27–30. doi:10.1016/0968-0004(91)90012-K. PMID 2053134.
Stemberger K, Pallhuber J, Doblinger A et al. (2004). "Secretoneurin in the human aqueous humor and the absence of an effect of frequently used eye drops on the levels.". Peptides 25 (12): 2115–8. doi:10.1016/j.peptides.2004.08.010. PMID 15572199.
Scammell JG, Reddy S, Valentine DL et al. (2000). "Isolation and characterization of the human secretogranin II gene promoter.". Brain Res. Mol. Brain Res. 75 (1): 8–15. doi:10.1016/S0169-328X(99)00269-7. PMID 10648883.
Kähler CM, Schratzberger P, Kaufmann G et al. (2002). "Transendothelial migration of leukocytes and signalling mechanisms in response to the neuropeptide secretoneurin.". Regul. Pept. 105 (1): 35–46. doi:10.1016/S0167-0115(01)00379-2. PMID 11853870.
Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F (2006). "Phosphoproteomic analysis of the human pituitary.". Pituitary 9 (2): 109–20. doi:10.1007/s11102-006-8916-x. PMID 16807684.
Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Kato A, Kammen-Jolly K, Fischer-Colbie R et al. (2000). "Co-distribution patterns of chromogranin B-like immunoreactivity with chromogranin A and secretoneurin within the human brainstem.". Brain Res. 852 (2): 444–52. doi:10.1016/S0006-8993(99)02229-5. PMID 10678772.
Schrott-Fischer A, Bitsche M, Humpel C et al. (2009). "Chromogranin peptides in amyotrophic lateral sclerosis.". Regul. Pept. 152 (1-3): 13–21. doi:10.1016/j.regpep.2008.07.009. PMID 18721831.
Fischer-Colbrie R, Kirchmair R, Kähler CM et al. (2005). "Secretoneurin: a new player in angiogenesis and chemotaxis linking nerves, blood vessels and the immune system.". Curr. Protein Pept. Sci. 6 (4): 373–85. doi:10.2174/1389203054546334. PMID 16101435.
Hillier LW, Graves TA, Fulton RS et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Lankat-Buttgereit B, Müller S, Schmidt H et al. (2008). "Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a neuroendocrine cell line.". Biol. Cell 100 (12): 703–15. doi:10.1042/BC20080052. PMID 18549351.
Stridsberg M, Eriksson B, Janson ET (2008). "Measurements of secretogranins II, III, V and proconvertases 1/3 and 2 in plasma from patients with neuroendocrine tumours.". Regul. Pept. 148 (1-3): 95–8. doi:10.1016/j.regpep.2008.03.007. PMID 18448176.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wen G, Wessel J, Zhou W et al. (2007). "An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension.". Hum. Mol. Genet. 16 (14): 1752–64. doi:10.1093/hmg/ddm123. PMC 2695823. PMID 17584765.
Yon L, Guillemot J, Montero-Hadjadje M et al. (2003). "Identification of the secretogranin II-derived peptide EM66 in pheochromocytomas as a potential marker for discriminating benign versus malignant tumors.". J. Clin. Endocrinol. Metab. 88 (6): 2579–85. doi:10.1210/jc.2002-021748. PMID 12788858.
Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wu C, Ma MH, Brown KR et al. (2007). "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.". Proteomics 7 (11): 1775–85. doi:10.1002/pmic.200601006. PMID 17474147.
Li L, Hung AC, Porter AG (2008). "Secretogranin II: a key AP-1-regulated protein that mediates neuronal differentiation and protection from nitric oxide-induced apoptosis of neuroblastoma cells.". Cell Death Differ. 15 (5): 879–88. doi:10.1038/cdd.2008.8. PMID 18239671.

References

↑ Gerdes HH, Rosa P, Phillips E, Baeuerle PA, Frank R, Argos P, Huttner WB (July 1989). "The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation". J. Biol. Chem. 264 (20): 12009–15. PMID 2745426.
↑ "Entrez Gene: SCG2".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.