SCAMP1

Secretory carrier membrane protein 1

Identifiers

SCAMP1 ; SCAMP; SCAMP37

External IDs

OMIM: 606911 MGI: 1349480 HomoloGene: 37975 GeneCards: SCAMP1 Gene

Gene ontology
Molecular function	• protein binding
Cellular component	• trans-Golgi network • integral component of membrane • clathrin-coated vesicle • recycling endosome membrane
Biological process	• post-Golgi vesicle-mediated transport • protein transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000085365

ENSMUSG00000021687

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
77.66 – 77.78 Mb

Chr 13:
94.2 – 94.29 Mb

PubMed search

Secretory carrier-associated membrane protein 1 is a protein that in humans is encoded by the SCAMP1 gene.^[1]^[2]

This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways.^[2]

Interactions

SCAMP1 has been shown to interact with ITSN1^[3] and AP1GBP1.^[3]

References

↑ Singleton DR, Wu TT, Castle JD (November 1997). "Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions". J Cell Sci. 110. ( Pt 17): 2099–107. PMID 9378760.
↑ 2.0 2.1 "Entrez Gene: SCAMP1 secretory carrier membrane protein 1".
↑ 3.0 3.1 Fernández-Chacón, R; Achiriloaie M; Janz R; Albanesi J P; Südhof T C (April 2000). "SCAMP1 function in endocytosis". J. Biol. Chem. (UNITED STATES) 275 (17): 12752–6. doi:10.1074/jbc.275.17.12752. ISSN 0021-9258. PMID 10777571.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Brand SH, Castle JD (1993). "SCAMP 37, a new marker within the general cell surface recycling system.". EMBO J. 12 (10): 3753–61. PMC 413657. PMID 8404846.
Andersson B, Wentland MA, Ricafrente JY et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Wu TT, Castle JD (1997). "Evidence for colocalization and interaction between 37 and 39 kDa isoforms of secretory carrier membrane proteins (SCAMPs).". J. Cell. Sci. 110. ( Pt 13): 1533–41. PMID 9224770.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Mao M, Fu G, Wu JS et al. (1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
Wu TT, Castle JD (1999). "Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor.". Mol. Biol. Cell 9 (7): 1661–74. doi:10.1091/mbc.9.7.1661. PMC 25404. PMID 9658162.
Fernández-Chacón R, Achiriloaie M, Janz R et al. (2000). "SCAMP1 function in endocytosis.". J. Biol. Chem. 275 (17): 12752–6. doi:10.1074/jbc.275.17.12752. PMID 10777571.
Zhang QH, Ye M, Wu XY et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Bell AW, Ward MA, Blackstock WP et al. (2001). "Proteomics characterization of abundant Golgi membrane proteins.". J. Biol. Chem. 276 (7): 5152–65. doi:10.1074/jbc.M006143200. PMID 11042173.
Fernández-Chacón R, Südhof TC (2001). "Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions.". J. Neurosci. 20 (21): 7941–50. PMID 11050114.
Guo Z, Liu L, Cafiso D, Castle D (2002). "Perturbation of a very late step of regulated exocytosis by a secretory carrier membrane protein (SCAMP2)-derived peptide.". J. Biol. Chem. 277 (38): 35357–63. doi:10.1074/jbc.M202259200. PMID 12124380.
Liu L, Guo Z, Tieu Q et al. (2003). "Role of secretory carrier membrane protein SCAMP2 in granule exocytosis.". Mol. Biol. Cell 13 (12): 4266–78. doi:10.1091/mbc.E02-03-0136. PMC 138632. PMID 12475951.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lin PJ, Williams WP, Luu Y et al. (2005). "Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7.". J. Cell. Sci. 118 (Pt 9): 1885–97. doi:10.1242/jcs.02315. PMID 15840657.