SB 203580

SB 203580^[1]

Names
IUPAC name 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
Other names RWJ-64809;
Identifiers
CAS Registry Number	152121-47-6 Y
ChEMBL	ChEMBL10 N
ChemSpider	153453 N
InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) N Key: CDMGBJANTYXAIV-UHFFFAOYSA-N N InChI=1/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) Key: CDMGBJANTYXAIV-UHFFFAOYAY
Jmol-3D images	Image
PubChem	176155
SMILES CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
Properties
Chemical formula	C21H16FN3OS
Molar mass	377.43 g/mol
Appearance	White to off-white solid
Solubility in DMSO	50 mg/mL
Hazards
Main hazards	Xn
R-phrases	R22 R41
S-phrases	S26 S39
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
N verify (what is: Y/N?)
Infobox references

SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27. At low concentrations, it does not inhibit JNK activity.

References