SBF1
| SET binding factor 1 | |||||||||||||
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 PDB rendering based on 1v5u. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SBF1 ; CMT4B3; DENND7A; MTMR5 | ||||||||||||
| External IDs | OMIM: 603560 MGI: 1925230 HomoloGene: 84710 GeneCards: SBF1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6305 | 77980 | |||||||||||
| Ensembl | ENSG00000100241 | ENSMUSG00000036529 | |||||||||||
| UniProt | O95248 | Q6ZPE2 | |||||||||||
| RefSeq (mRNA) | NM_002972 | NM_001081030 | |||||||||||
| RefSeq (protein) | NP_002963 | NP_001074499 | |||||||||||
| Location (UCSC) | Chr 22: 50.88 – 50.91 Mb | Chr 15: 89.29 – 89.32 Mb | |||||||||||
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Myotubularin-related protein 5 is a protein that in humans is encoded by the SBF1 gene.[1][2][3]
Interactions
SBF1 has been shown to interact with MTMR2[4] and SUV39H1.[5]
References
- ↑ Cui X, De Vivo I, Slany R, Miyamoto A, Firestein R, Cleary ML (April 1998). "Association of SET domain and myotubularin-related proteins modulates growth control". Nat. Genet. 18 (4): 331–7. doi:10.1038/ng0498-331. PMID 9537414.
- ↑ Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N et al. (December 1998). "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human". Hum. Mol. Genet. 7 (11): 1703–12. doi:10.1093/hmg/7.11.1703. PMID 9736772.
- ↑ "Entrez Gene: SBF1 SET binding factor 1".
- ↑ Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon JE (April 2003). "Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4492–7. doi:10.1073/pnas.0431052100. PMC 153583. PMID 12668758.
- ↑ Firestein R, Cui X, Huie P, Cleary ML (July 2000). "Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9". Mol. Cell. Biol. 20 (13): 4900–9. doi:10.1128/MCB.20.13.4900-4909.2000. PMC 85941. PMID 10848615.
Further reading
- Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- Firestein R, Cui X, Huie P, Cleary ML (2000). "Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9". Mol. Cell. Biol. 20 (13): 4900–9. doi:10.1128/MCB.20.13.4900-4909.2000. PMC 85941. PMID 10848615.
- Firestein R, Cleary ML (2001). "Pseudo-phosphatase Sbf1 contains an N-terminal GEF homology domain that modulates its growth regulatory properties". J. Cell. Sci. 114 (Pt 16): 2921–7. PMID 11686296.
- Firestein R, Nagy PL, Daly M, Huie P, Conti M, Cleary ML (2002). "Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1". J. Clin. Invest. 109 (9): 1165–72. doi:10.1172/JCI12589. PMC 150957. PMID 11994405.
- Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon JE (2003). "Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4492–7. doi:10.1073/pnas.0431052100. PMC 153583. PMID 12668758.
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