SATB1

SATB homeobox 1

PDB rendering based on 1yse.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1YSE, 2L1P, 2O49, 2O4A, 3NZL, 3TUO

Identifiers

Symbol

SATB1

External IDs

OMIM: 602075 MGI: 105084 HomoloGene: 2232 GeneCards: SATB1 Gene

Gene ontology
Molecular function	• chromatin binding • double-stranded DNA binding • sequence-specific DNA binding transcription factor activity • protein binding • sequence-specific DNA binding
Cellular component	• nucleus • nucleoplasm • nuclear heterochromatin • nuclear matrix • PML body
Biological process	• negative regulation of transcription from RNA polymerase II promoter • chromatin organization • chromatin remodeling • transcription, DNA-templated • apoptotic process • cellular component disassembly involved in execution phase of apoptosis • epidermis development • viral process • histone methylation • CD4-positive, alpha-beta T cell differentiation • CD8-positive, alpha-beta T cell differentiation • activated T cell proliferation • reflex
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
18.39 – 18.49 Mb

Chr 17:
51.74 – 51.83 Mb

PubMed search

SATB1 (special AT-rich sequence-binding protein-1) is a protein which in humans is encoded by the SATB1 gene.^[1]

Function

SATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chromatin architecture with gene regulation.^[2] Recent studies have unraveled the role of SATB1 in organization of chromatin 'loopscape' and its dynamic nature in response to physiological stimuli.^[3] At genome-wide level, SATB1 seems to play a role in organization of the transcriptionally poised chromatin. SATB1 organizes the MHC class-I locus into distinct chromatin loops by tethering MARs to nuclear matrix at fixed distances. Silencing of SATB1 mimics the effects of IFN-γ treatment on chromatin loop architecture of the MHC class I locus and altered expression of genes within the locus. SATB1 has also been shown to induce breast cancer tumor growth and metastasis through the altered expression of large numbers of genes.

Interactions

SATB1 has been shown to interact with HDAC1,^[4] SMARCA5,^[4] MTA2,^[4] CHD4,^[4] CUTL1,^[5] POLR2J^[6] and BAZ1A.^[4]

References

↑ "Entrez Gene: SATB1 SATB homeobox 1".
↑ Pavan Kumar P, Purbey PK, Sinha CK, Notani D, Limaye A, Jayani RS, Galande S (April 2006). "Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo". Mol. Cell 22 (2): 231–43. doi:10.1016/j.molcel.2006.03.010. PMID 16630892.
↑ Galande S, Purbey PK, Notani D, Kumar PP (October 2007). "The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1". Curr. Opin. Genet. Dev. 17 (5): 408–14. doi:10.1016/j.gde.2007.08.003. PMID 17913490.
↑ 4.0 4.1 4.2 4.3 4.4 Yasui, Dag; Miyano Masaru, Cai Shutao, Varga-Weisz Patrick, Kohwi-Shigematsu Terumi (October 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature (England) 419 (6907): 641–5. doi:10.1038/nature01084. ISSN 0028-0836. PMID 12374985.
↑ Liu, J; Barnett A; Neufeld E J; Dudley J P (July 1999). "Homeoproteins CDP and SATB1 Interact: Potential for Tissue-Specific Regulation". Mol. Cell. Biol. (UNITED STATES) 19 (7): 4918–26. ISSN 0270-7306. PMC 84297. PMID 10373541.
↑ Durrin, Linda K; Krontiris Theodore G (June 2002). "The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11". Genomics (United States) 79 (6): 809–17. doi:10.1006/geno.2002.6772. ISSN 0888-7543. PMID 12036295.

Dickinson LA, Joh T, Kohwi Y, Kohwi-Shigematsu T (1992). "A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition". Cell 70 (4): 631–45. doi:10.1016/0092-8674(92)90432-C. PMID 1505028.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Nakagomi K, Kohwi Y, Dickinson LA, Kohwi-Shigematsu T (1994). "A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1". Mol. Cell. Biol. 14 (3): 1852–60. PMC 358543. PMID 8114718.
Xu L, Deng HX, Xia JH et al. (1997). "Assignment of SATB1 to human chromosome band 3p23 by in situ hybridization". Cytogenet. Cell Genet. 77 (3–4): 205–6. doi:10.1159/000134577. PMID 9284917.
Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method". Genomics 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904.
Escalier D, Allenet B, Badrichani A, Garchon HJ (1999). "High level expression of the Xlr nuclear protein in immature thymocytes and colocalization with the matrix-associated region-binding SATB1 protein". J. Immunol. 162 (1): 292–8. PMID 9886398.
Liu J, Barnett A, Neufeld EJ, Dudley JP (1999). "Homeoproteins CDP and SATB1 Interact: Potential for Tissue-Specific Regulation". Mol. Cell. Biol. 19 (7): 4918–26. PMC 84297. PMID 10373541.
Galande S, Dickinson LA, Mian IS et al. (2001). "SATB1 Cleavage by Caspase 6 Disrupts PDZ Domain-Mediated Dimerization, Causing Detachment from Chromatin Early in T-Cell Apoptosis". Mol. Cell. Biol. 21 (16): 5591–604. doi:10.1128/MCB.21.16.5591-5604.2001. PMC 87280. PMID 11463840.
Kieffer LJ, Greally JM, Landres I et al. (2002). "Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3". J. Immunol. 168 (8): 3915–22. doi:10.4049/jimmunol.168.8.3915. PMID 11937547.
Durrin LK, Krontiris TG (2002). "The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11". Genomics 79 (6): 809–17. doi:10.1006/geno.2002.6772. PMID 12036295.
Yasui D, Miyano M, Cai S et al. (2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature 419 (6907): 641–5. doi:10.1038/nature01084. PMID 12374985.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cai S, Han HJ, Kohwi-Shigematsu T (2003). "Tissue-specific nuclear architecture and gene expression regulated by SATB1". Nat. Genet. 34 (1): 42–51. doi:10.1038/ng1146. PMID 12692553.
Fujii Y, Kumatori A, Nakamura M (2004). "SATB1 makes a complex with p300 and represses gp91(phox) promoter activity". Microbiol. Immunol. 47 (10): 803–11. doi:10.1111/j.1348-0421.2003.tb03438.x. PMID 14605447.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gocke CB, Yu H, Kang J (2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates". J. Biol. Chem. 280 (6): 5004–12. doi:10.1074/jbc.M411718200. PMID 15561718.
Wen J, Huang S, Rogers H et al. (2005). "SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression". Blood 105 (8): 3330–9. doi:10.1182/blood-2004-08-2988. PMID 15618465.
Seo J, Lozano MM, Dudley JP (2005). "Nuclear matrix binding regulates SATB1-mediated transcriptional repression". J. Biol. Chem. 280 (26): 24600–9. doi:10.1074/jbc.M414076200. PMID 15851481.
Nakayama Y, Mian IS, Kohwi-Shigematsu T, Ogawa T (2006). "A nuclear targeting determinant for SATB1, a genome organizer in the T cell lineage". Cell Cycle 4 (8): 1099–106. PMID 15970696.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

PDB gallery

1yse: Solution structure of the MAR-binding domain of SATB1

SATB1

Function

Interactions

References

Further reading