SAP18

Sin3A-associated protein, 18kDa

PDB rendering based on 2hde.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsSAP18 ; 2HOR0202; SAP18P
External IDsOMIM: 602949 MGI: 1277978 HomoloGene: 4289 GeneCards: SAP18 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1028420220
EnsemblENSG00000150459ENSMUSG00000021963
UniProtO00422O55128
RefSeq (mRNA)NM_005870NM_009119
RefSeq (protein)NP_005861NP_033145
Location (UCSC)Chr 13:
21.71 – 21.72 Mb		Chr 14:
57.8 – 57.8 Mb
PubMed search

Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene.[1][2]

Function

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.[2] Additionally, SAP18s splice variants are implicated in apoptotic cycles.[3]

Interactions

SAP18 has been shown to interact with

References

  1. ↑ Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (Jun 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell 89 (3): 357–64. doi:10.1016/S0092-8674(00)80216-0. PMID 9150135.
  2. ↑ 2.0 2.1 "Entrez Gene: SAP18 Sin3A-associated protein, 18kDa".
  3. ↑ Michelle L, Cloutier A, Toutant J, Shkreta L, Thibault P, Durand M, Garneau D, Gendron D, Lapointe E, Couture S, Le Hir H, Klinck R, Abou Elela S, Prinos P, Chabot B (December 2011). "Proteins Associated with the Exon Junction Complex Also Control the Alternative Splicing of Apoptotic Regulators". Mol Cell Biol 32 (5): 954–67. doi:10.1128/MCB.06130-11. PMC 3295189. PMID 22203037.
  4. ↑ Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (March 2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". J. Biochem. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.
  5. ↑ Cheng SY, Bishop JM (April 2002). "Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5442–7. doi:10.1073/pnas.082096999. PMC 122788. PMID 11960000.
  6. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

External links