Revaprazan
Revaprazan
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Systematic (IUPAC) name |
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N-(4-Fluorophenyl)-4,5-dimethyl-6-(1-methyl-3,4-dihydro-2(1H)-isoquinolinyl)-2-pyrimidinamine |
Clinical data |
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Trade names |
Revanex[1] |
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Identifiers |
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199463-33-7 |
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None |
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PubChem |
CID 204104 |
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ChemSpider |
176801 |
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Synonyms |
YH1885 |
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Chemical data |
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Formula |
C22H23FN4 |
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362.44 g/mol |
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SMILES
- CC1C2=CC=CC=C2CCN1C3=NC(=NC(=C3C)C)NC4=CC=C(C=C4)F
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InChI=1S/C22H23FN4/c1-14-15(2)24-22(25-19-10-8-18(23)9-11-19)26-21(14)27-13-12-17-6-4-5-7-20(17)16(27)3/h4-11,16H,12-13H2,1-3H3,(H,24,25,26)
Key:LECZXZOBEZITCL-UHFFFAOYSA-N
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Revaprazan (trade name Revanex) is a drug that reduces gastric acid secretion which is used for the treatment of gastritis.[2] It acts as an acid pump antagonist[3] (potassium-competitive acid blocker). Revaprazan is approved for use in Korea,[4] but is not approved in Europe or the United States.
References
- ↑ "Revaprazan". drugs.com.
- ↑ Kim HK, Park SH, Cheung DY, Cho YS, Kim JI, Kim SS, Chae HS, Kim JK, Chung IS (Oct 2010). "Clinical trial: inhibitory effect of revaprazan on gastric acid secretion in healthy male subjects". J Gastroenterol Hepatol 25 (10): 1618–1625. doi:10.1111/j.1440-1746.2010.06408.x. PMID 20880169.
- ↑ Yu KS, Bae KS, Shon JH, Cho JY, Yi SY, Chung JY, Lim HS, Jang IJ, Shin SG, Song KS, Moon BS (Jan 2004). "Pharmacokinetic and pharmacodynamic evaluation of a novel proton pump inhibitor, YH1885, in healthy volunteers". J Clin Pharmacol 44 (1): 73–82. doi:10.1177/0091270003261321. PMID 14681344.
- ↑ "Revaprazan Yuhan registered, South Korea (gastritis)". R & D Focus Drug News. September 25, 2006.
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| H2 antagonists ("-tidine") | |
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| Prostaglandins (E)/analogues ("-prost-") | |
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| Proton-pump inhibitors ("-prazole") | |
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| Potassium-competitive acid blockers ("-prazan") | |
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| Other | |
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| Description |
- Anatomy
- Physiology
- Development
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| Disease |
- Congenital
- Neoplasms and cancer
- Inflammatory bowel disease
- Gluten sensitivity
- Other
- Symptoms and signs
- Blood tests
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| Treatment |
- Procedures
- Drugs
- anabolic steroids
- antacids
- diarrhoea and infection
- bile and liver
- functional gastrointestinal disorders
- laxatives
- peptic ulcer and reflux
- nausea and vomiting
- other
- Surgery
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