Relaxin/insulin-like family peptide receptor 1

PDB rendering based on 2jm4.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2JM4, 2M7P

Identifiers

Symbols

RXFP1 ; LGR7; RXFPR1

External IDs

OMIM: 606654 MGI: 2682211 HomoloGene: 11007 IUPHAR: 351 ChEMBL: 1293316 GeneCards: RXFP1 Gene

Gene ontology
Molecular function	• G-protein coupled receptor activity • protein binding • hormone binding • metal ion binding
Cellular component	• plasma membrane • integral component of membrane
Biological process	• adenylate cyclase-modulating G-protein coupled receptor signaling pathway • parturition • cell differentiation • extracellular matrix organization • lung connective tissue development • nipple morphogenesis
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
158.32 – 158.65 Mb

Chr 3:
79.64 – 79.74 Mb

PubMed search

Relaxin/insulin-like family peptide receptor 1, also known as RXFP1, is a human G protein coupled receptor that is one of the relaxin receptors.^[1]

References

↑ "Entrez Gene: RXFP1 relaxin/insulin-like family peptide receptor 1".

External links

"Relaxin Family Peptide Receptors: RXFP1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Bathgate RA, Ivell R, Sanborn BM et al. (2005). "Receptors for relaxin family peptides". Ann. N. Y. Acad. Sci. 1041: 61–76. doi:10.1196/annals.1282.010. PMID 15956688.
Bathgate RA, Ivell R, Sanborn BM et al. (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880.
Hsu SY, Kudo M, Chen T et al. (2001). "The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7". Mol. Endocrinol. 14 (8): 1257–71. doi:10.1210/me.14.8.1257. PMID 10935549.
Bartsch O, Bartlick B, Ivell R (2001). "Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity". Mol. Hum. Reprod. 7 (9): 799–809. doi:10.1093/molehr/7.9.799. PMID 11517286.
Hsu SY, Nakabayashi K, Nishi S et al. (2002). "Activation of orphan receptors by the hormone relaxin". Science 295 (5555): 671–4. doi:10.1126/science.1065654. PMID 11809971.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sudo S, Kumagai J, Nishi S et al. (2003). "H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2". J. Biol. Chem. 278 (10): 7855–62. doi:10.1074/jbc.M212457200. PMID 12506116.
Ivell R, Balvers M, Pohnke Y et al. (2004). "Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates". Reprod. Biol. Endocrinol. 1: 114. doi:10.1186/1477-7827-1-114. PMC 293425. PMID 14633277.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Luna JJ, Riesewijk A, Horcajadas JA et al. (2004). "Gene expression pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle". Mol. Hum. Reprod. 10 (2): 85–90. doi:10.1093/molehr/gah019. PMID 14742692.
Bond CP, Parry LJ, Samuel CS et al. (2004). "Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle". J. Clin. Endocrinol. Metab. 89 (7): 3477–85. doi:10.1210/jc.2003-030798. PMID 15240635.
Liu C, Chen J, Kuei C et al. (2005). "Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7". Mol. Pharmacol. 67 (1): 231–40. doi:10.1124/mol.104.006700. PMID 15465925.
Scott DJ, Layfield S, Riesewijk A et al. (2005). "Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7". Clin. Exp. Pharmacol. Physiol. 31 (11): 828–32. doi:10.1111/j.1440-1681.2004.04075.x. PMID 15566402.
Büllesbach EE, Schwabe C (2005). "The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7". J. Biol. Chem. 280 (14): 14051–6. doi:10.1074/jbc.M500030200. PMID 15695505.
Tang M, Mazella J, Zhu HH, Tseng L (2005). "Ligand activated relaxin receptor increases the transcription of IGFBP-1 and prolactin in human decidual and endometrial stromal cells". Mol. Hum. Reprod. 11 (4): 237–43. doi:10.1093/molehr/gah149. PMID 15722441.
Hopkins EJ, Bathgate RA, Gooley PR (2005). "The human LGR7 low-density lipoprotein class A module requires calcium for structure". Ann. N. Y. Acad. Sci. 1041: 27–34. doi:10.1196/annals.1282.006. PMID 15956684.
Bond CP, Parry LJ, Samuel CS et al. (2005). "Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle". Ann. N. Y. Acad. Sci. 1041: 136–43. doi:10.1196/annals.1282.020. PMID 15956698.
Halls ML, Bathgate RA, Summers RJ (2005). "Signal switching after stimulation of LGR7 receptors by human relaxin 2". Ann. N. Y. Acad. Sci. 1041: 288–91. doi:10.1196/annals.1282.042. PMID 15956719.
Muda M, He C, Martini PG et al. (2005). "Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity". Mol. Hum. Reprod. 11 (8): 591–600. doi:10.1093/molehr/gah205. PMID 16051677.

PDB gallery

2jm4: The solution NMR structure of the relaxin (RXFP1) receptor LDLa module.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3

Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)

Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)

Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine (D1 D2 D3 D4 D5) Histamine (H1 H2 H3 H4) Melatonin (1A 1B 1C) TAAR (1 2 3 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 (1 2) FPRL1 OXE Prostaglandin (DP (1 2), EP (1 2 3 4), FP) Prostacyclin Thromboxane

Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Lactate Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Niacin (1 2) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide	B/W (1 2) FF (1 2) S Y (1 2 4 5) Neuromedin (B U (1 2)) Neurotensin (1 2)

Other	Anaphylatoxin (C3a C5a) Angiotensin (1 2) Apelin Bombesin (BRS3 GRPR NMBR) Bradykinin (B1 B2) Chemokine Cholecystokinin (A B) Endothelin (A B) Formyl peptide (1 2 3) FSH Galanin (1 2 3) GHB receptor Gonadotropin-releasing hormone (1 2) Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS (1 1L D E F G X1 X2 X3 X4) Melanocortin (1 2 3 4 5) MCHR (1 2) Motilin Opioid (Delta Kappa Mu Nociceptin & Zeta, but not Sigma) Orexin (1 2) Oxytocin Prokineticin (1 2) Prolactin-releasing peptide Relaxin (1 2 3 4) Somatostatin (1 2 3 4 5) Tachykinin (1 2 3) Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin (1A 1B 2)

Miscellaneous

Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)

Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin like

Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)

Adhesion	ADGRG (1 2 3 4 5 6 7)

Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth hormone releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste	TAS1R (1 2 3) TAS2R (1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60)

Other	Calcium-sensing receptor GABA B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled / Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)

Smoothened	Smoothened

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR

Relaxin/insulin-like family peptide receptor 1

See also

References

External links

Further reading