Raja M. Flores
| Raja Michael Flores, M.D. | |
|---|---|
| Education |
Columbia University New York University Albert Einstein College of Medicine |
|
Medical career | |
| Profession | thoracic surgeon |
| Institutions | Mount Sinai Hospital |
| Research | cancer research |
Raja Michael Flores, M.D., is an American thoracic surgeon, currently Chief of the Division of Thoracic Surgery at Mount Sinai Hospital and Ames Professor of Cardiothoracic Surgery at the Icahn School of Medicine at Mount Sinai, both in New York City.[1]
Biography
Flores received a B.A. in biochemistry from New York University in 1988 and his M.D. from Albert Einstein College of Medicine in 1992. His internship (1992–1993) and residency (1993–1997) at Columbia-Presbyterian Medial Center were followed by a Thoracic Oncology Clinical Research Fellowship (1997–1998) in Intraoperative Chemotherapy, Mesothelioma and Lung Cancer at Brigham and Women's Hospital/Dana-Farber Cancer Institute, and a Cardiothoracic Surgery Residency (1998-200) at Harvard Medical School, both in Boston, Massachusetts.[2][3]
Flores is currently an editorial board member for the World Journal of Gastrointestinal Surgery, the World Journal of Gastrointestinal Edoscopy and the World Journal of Respirology. He is a reviewer for 13 other journals including Head & Neck, the Journal of Thoracic and Cardiovascular Surgery, the Journal of Thoracic Oncology and the Journal of Clinical Oncology. Memberships include the American College of Chest Physicians, the American College of Surgeons Oncology Group and the American Society of Clinical Oncology.[4]
Research
Flores' research has significantly impacted the surgical management of pleural mesothelioma by demonstrating that partial pleural membrane removal is as effective a treatment as lung removal.[5] He was instrumental in creating VATS lobectomy as the standard in the surgical treatment of lung cancer[6][7][8] and is considered a pioneer in the use of intraoperative chemotherapy for mesothelioma.[9]
Flores is the author of more than 60 book chapters, reviews, monographs and abstracts and more than 150 publications. He serves as a reviewer for 13 journals and has been an editorial board member on four journals. He is the principal investigator on five clinical trials and has been ranked in the top 1% in his field by U.S. News & World Report.[5][10]
Flores areas of interest include lung cancer screening, thoracoscopy, VATS lobectomy, extrapleural pneumonectomy for mesothelioma, asbestos, tracheal stenosis, carinal surgery and esophageal cancer surgery.[11] He is the principal investigator for a clinical trial of neoadjuvant gemcitabine and cisplatin followed by extrapleural pneumonectomy and high-dose radiation.[4]
Other research includes:
| Role | Title | Affiliation |
|---|---|---|
| Co-Principal Investigator | Extrapleural Pneumonectomy Followed by Intrathoracic/Intraperitoneal Heated Cisplatin and Intravenous Sodium Thiosulfate in the Multimodality Treatment of Malignant Pleural Mesothelioma: A Phase I Study | Brigham & Women's Hospital |
| Principal Investigator | Randomized, Prospective Trial of Mediastinal LN Sampling Vs. Complete Lymphadenectomy During Conduct of Pulmonary Resection in Patients with N0 and N1 (less than hilar) non-small cell carcinoma (ACOSOG Z0030) | Memorial Sloan-Kettering Cancer Center |
| Principal Investigator | A Randomized Phase III Trial Surgery Alone or Surgery Plus Preoperative
Paclitaxel/Carboplatin in Clinical Stage IB (T2N0), II (T1-2N1, T3N0) and selected IIIA None Small Cell Lung Cancer (NSCLC) – (RTOGL-0015 (S9900) |
Memorial Sloan-Kettering Cancer Center |
| Principal Investigator | The Role of Laparoscopic Staging in Patients with Resectable Gastroesophageal Junction Carcinomas | Memorial Sloan-Kettering Cancer Center |
| Principal Investigator | A Phase II Trial of Induction Chemotherapy, Surgical Resection and Adjuvant External Beam Radiation for Locally Advanced Malignant Pleural Mesothelioma | Memorial Sloan-Kettering Cancer Center |
| Principal Investigator | A Phase II Trial of Induction Chemotherapy, Surgical Resection, and Adjuvant External Beam Radiation for Locally Advanced Malignant Pleural Mesothelioma | Lilly Research Laboratories |
Publications
Partial list:
- Flores RM, Ihekweazu UN, Rizk NP, Dycoco J, Bains MS, Downey RJ, Adusumilli PS. Patterns of recurrence and incidence of second primary tumors after lobectomy by VATS versus thoracotomy for lung cancer. J Thorac Cardiovasc Surg 2011 Jan;141(1):59-64. PMID 21055770
- Kaufman AJ, Flores RM. Surgical treatment of malignant pleural mesothelioma. Curr Treat Options Oncol. 2011 Jun;12(2):201-16. PMID 21465419.
- Flores RM. Reply to difference in outcome in the transection of the pulmonary artery and vein. J Thorac Cardiovasc Surg. 2011 Feb;141(2):597-8. PMID 21241869.
- Rai AJ, Flores RM. Association of malignant mesothelioma and asbestos related conditions with ovarian cancer: shared biomarkers and a possible etiological link? Clin Chem Lab Med. 2011 Jan;49(1):5-7. Epub 2010 Dec 16. PMID 21158701.
- Flores RM, Ihekweazu UN, Rizk N, Dycoco J, Bains MS, Downey RJ, Adusumilli P, Finley DJ, Huang J, Rusch VW, Sarkaria I, Park B. Patterns of recurrence and incidence of second primary tumors after lobectomy by means of video-assisted thoracoscopic surgery (VATS) versus thoracotomy for lung cancer. J Thorac Cardiovasc Surg. 2011 Jan;141(1):59-64. Epub 2010 Nov 5. PMID 21055770.
- Flores RM, Riedel E, Donington JS, Alago W, Ihekweazu U, Krug L, Rosenzweig K, Adusumilli PS, Carbone M, Pass HI. Frequency of use and predictors of cancer-directed surgery in the management of malignant pleural mesothelioma in a community-based (Surveillance, Epidemiology, and End Results [SEER]) population. J Thorac Oncol. 2010 Oct;5(10):1649-54. PMID 20871264.
- Ihekweazu UN, Ludwig E, Flores RM. PillCam in gastric conduit after Ivor Lewis esophagectomy. Ann Thorac Surg. 2010 Aug;90(2):673. PMID 20667385.
- Abbey AM, Flores RM. Spontaneous resolution of a pericardial cyst. Ann Thorac Cardiovasc Surg. 2010 Aug;16(1):55-6. PMID 20190713.
- Rai AJ, Flores RM, Mathew A, Gonzalez-Espinoza R, Bott M, Ladanyi M, Rusch V, Fleisher M. Soluble mesothelin related peptides (SMRP) and osteopontin as protein biomarkers for malignant mesothelioma: analytical validation of ELISA based assays and characterization at mRNA and protein levels. Clin Chem Lab Med. 2010 Feb;48(2):271-8. PMID 20131968.
- Flores RM. Invited commentary. Ann Thorac Surg. 2010 Feb;89(2):396. PMID 20103307.
- Blasberg JD, Pass HI, Goparaju CM, Flores RM, Lee S, Donington JS. Reduction of elevated plasma osteopontin levels with resection of non-small-cell lung cancer. J Clin Oncol. 2010 Feb 20;28(6):936-41. Epub 2010 Jan 19. PMID 20085934
- Flores RM. Video-assisted thoracic surgery (VATS) lobectomy: focus on technique. World J Surg. 2010 Apr;34(4):616-20. PMID 20082195.
- Blasberg JD, Pass HI, Goparaju CMV, Flores RM, Lee S., Donington JS. Reduction of elevated plasma osteopontin levels with resection of non-small cell lung cancer. J Clin Oncol 2010 Feb 20;28(6):936-41. PMID 20085934
- Flores RM. Video-assisted thoracic surgery (VATS) lobectomy: focus on technique.World J Surg. 2010 Apr;34(4):616-20. PMID 20082195
- Flores RM, Riedel E, Donington JS, Alago W, Ihekweazu U, Krug L, Rosenzweig K, Adusumilli PS, Carbone M, and Pass HI. Frequency of use and predictors of cancer directed surgery in the management of malignant pleural mesothelioma in a community-based (SEER) population. J Thorac Oncol 2010 Oct 5(10):1649-1654. PMID 20871264
- Flores RM. Surgical options in malignant pleural mesothelioma: extrapleural pneumonectomy or pleurectomy/decortication. Semin Thorac Cardiovasc Surg. 2009 Summer;21(2):149-53. Review. PMID 19822286.
- Flores RM, Park BJ, Dycoco J, Aronova A, Hirth Y, Rizk NP, Bains M, Downey RJ, Rusch VW. Lobectomy by video-assisted thoracic surgery (VATS) versus thoracotomy for lung cancer. J Thorac Cardiovasc Surg 2009;138(1):11-18. PMID 19577048
- Flores RM, Park BJ, Dycoco J, Aronova A, Hirth Y, Rizk NP, Bains M, Downey RJ, Rusch VW. Lobectomy by video-assisted thoracic surgery (VATS) versus thoracotomy for lung cancer. J Thorac Cardiovasc Surg. 2009 Jul;138(1):11-8. PMID 19577048.
- Flores RM, Pass HI, Seshan VE, Dycoco J, Zakowski M, Carbone M, Bains MS, Rusch VW. Extrapleural Pneumonectomy (EPP) versus Pleurectomy/Decortication (P/D) in the surgical management of malignant pleural mesothelioma (MPM): Results in 663 patients. J Thorac Cardiovasc Surg 2008 Mar; 135(3):620-6, 626.el-3. Epub 2008 Feb 1. PMID 18329481
- Garcia A, Flores RM. Surgical Management of tumors invading the superior vena cava. Ann Thorac Surg 2008; 85(6):2144-6. PMID 18498851
- Flores RM, Routledge T, Venkatraman E, Dycoco J, Hirth Y, Rusch VW. The impact of lymph node station on survival in 348 patients with surgically resected malignant pleural mesothelioma (MPM): implications for revision of the AJCC staging system. J Thorac Cardiovasc Surg 2008 Sep; 136(3): 605-610. Epub 2008 Jun 27. PMID 18805259
- Garcia A, Byrne JG, Bueno R, Flores RM. Aneurysm of the main pulmonary artery. Ann Thorac Cardiovasc Surg. 2008 Dec;14(6):399-401. PMID 19131930.
- Flores RM, Zakowski M, Venkatraman E, Krug L, Rosenzweig K, Dycoco J, Lee C, Yeoh C, Bains M, Rusch VW. Prognostic Factors in the Treatment of Malignant Pleural Mesothelioma (MPM) at a Large Tertiary Referral Center. J Thorac Oncol 2007;2:957-65. PMID 17909360
- Flores RM, Krug LM, Rosenzweig KE, Venkatraman E, Vincent A, Heelan R, Akhurst T, Rusch VW. Induction chemotherapy, extrapleural pneumonectomy, and postoperative high dose radiotherapy for locally advanced malignant pleural mesothelioma. A phase II trial. J Thorac Oncol 2006 May;1(4):289-95. PMID 17409872
- Flores RM, Alam N. Treatment of malignant pleural mesothelioma: pleurectomy with adjuvant therapy. Operative Techniques in Thor and Cardiovasc Surg 2006:11(1)57-74.
- Flores RM, Akhurst T, Gonen M, Zakowski M, Dycocco J, Larsen SM, Rusch VW. Positron emission tomography predicts survival in malignant pleural mesothelioma. J Thorac Cardiovasc 2006:132(4):763-8. PMID 17000285
- Flores RM, Su W, Lal D, Rusch VW, LaQuaglia MP. Extrapleural pneumonectomy in children. J Ped Surg 2006;41(10):1738-42. PMID 17011280
- Sugarbaker DJ, Flores RM, Jaklitsch MT, Richards WG, Strauss GM, Corson JM, DeCamp MM Jr, Swanson SJ, Bueno R, Lukanich JM, Baldini EH, Mentzer SJ. Resection margins, extrapleural nodal status, and cell type determine survival in trimodality therapy of malignant pleural mesothelioma (MPM): Results in 183 patients. Seventy-eighth meeting of the American Association of Thoracic Surgery. 1998. Boston, MA. PMID 9869758
References
- ↑ "Icahn School of Medicine at Mount Sinai - Raja M. Flores". Retrieved November 1, 2011.
- ↑ "Raja Flores, MD, Named Chief of Thoracic Surgery at The Mount Sinai Hospital". Retrieved November 1, 2011.
- ↑ "Dr. Raja M. Flores - Sharecare". Retrieved November 1, 2011.
- ↑ 4.0 4.1 "mesotheliomaweb.org". Retrieved November 1, 2011.
- ↑ 5.0 5.1 "Albert Einstein College of Medicine". Retrieved November 1, 2011.
- ↑ "Mesothelioma Resource Online". Retrieved November 1, 2011.
- ↑ "Society of Surgical Oncology". Retrieved November 1, 2011.
- ↑ "BusinessWeek". Retrieved November 1, 2011.
- ↑ "The ASCO Post". Retrieved November 1, 2011.
- ↑ "US News & World Report - Top Doctors". Retrieved November 1, 2011.
- ↑ "The Cardiothoracic Surgery Network". Retrieved November 1, 2011.
External links
- Mount Sinai Hospital homepage
- Icahn School of Medicine at Mount Sinai homepage
- YouTube – Dr. Flores at the International Symposium on Malignant Mesothelioma, 2008
- YouTube – Dr. Flores at the Mesothelioma Symposium, 2009