RYBP
| RING1 and YY1 binding protein | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | RYBP ; AAP1; DEDAF; YEAF1 | ||||||||||||
| External IDs | OMIM: 607535 MGI: 1929059 HomoloGene: 8159 GeneCards: RYBP Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 23429 | 56353 | |||||||||||
| Ensembl | ENSG00000163602 | ENSMUSG00000072872 | |||||||||||
| UniProt | Q8N488 | Q8CCI5 | |||||||||||
| RefSeq (mRNA) | NM_012234 | NM_019743 | |||||||||||
| RefSeq (protein) | NP_036366 | NP_062717 | |||||||||||
| Location (UCSC) | Chr 3: 72.42 – 72.5 Mb | Chr 6: 100.23 – 100.29 Mb | |||||||||||
| PubMed search | |||||||||||||
RING1 and YY1-binding protein is a protein that in humans is encoded by the RYBP gene.[1][2]
Interactions
RYBP has been shown to interact with RING1,[1][3] YY1,[1] Caspase 10,[4] E2F3,[5] E2F2,[5] Mdm2,[6] Abl gene[7] and CBX2.[1]
References
- ↑ 1.0 1.1 1.2 1.3 Garcia E, Marcos-Gutierrez C, del Mar Lorente M, Moreno JC, Vidal M (August 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.
- ↑ "Entrez Gene: RYBP RING1 and YY1 binding protein".
- ↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ↑ Zheng, L; Schickling O; Peter M E; Lenardo M J (August 2001). "The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm". J. Biol. Chem. (United States) 276 (34): 31945–52. doi:10.1074/jbc.M102799200. ISSN 0021-9258. PMID 11395500.
- ↑ 5.0 5.1 Schlisio, Susanne; Halperin Terri; Vidal Miguel; Nevins Joseph R (November 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". EMBO J. (England) 21 (21): 5775–86. doi:10.1093/emboj/cdf577. ISSN 0261-4189. PMC 131074. PMID 12411495.
- ↑ Chen, Deng; Zhang Jianbing; Li Mao; Rayburn Elizabeth R; Wang Hui; Zhang Ruiwen (February 2009). "RYBP stabilizes p53 by modulating MDM2". EMBO Rep. (England) 10 (2): 166–72. doi:10.1038/embor.2008.231. PMC 2637313. PMID 19098711.
- ↑ Zhu, J; Shore S K (Dec 1996). "c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein". Mol. Cell. Biol. (UNITED STATES) 16 (12): 7054–62. ISSN 0270-7306. PMC 231708. PMID 8943360.
Further reading
- Zhu J, Shore SK (1997). "c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein.". Mol. Cell. Biol. 16 (12): 7054–62. PMC 231708. PMID 8943360.
- Trimarchi JM, Fairchild B, Wen J, Lees JA (2001). "The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex.". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1519–24. doi:10.1073/pnas.041597698. PMC 29289. PMID 11171983.
- Zheng L, Schickling O, Peter ME, Lenardo MJ (2001). "The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm.". J. Biol. Chem. 276 (34): 31945–52. doi:10.1074/jbc.M102799200. PMID 11395500.
- Sawa C, Yoshikawa T, Matsuda-Suzuki F et al. (2002). "YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors.". J. Biol. Chem. 277 (25): 22484–90. doi:10.1074/jbc.M203060200. PMID 11953439.
- Schlisio S, Halperin T, Vidal M, Nevins JR (2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function.". EMBO J. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074. PMID 12411495.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Guelen L, Paterson H, Gäken J et al. (2004). "TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.". Oncogene 23 (5): 1153–65. doi:10.1038/sj.onc.1207224. PMID 14691460.
- Danen-van Oorschot AA, Voskamp P, Seelen MC et al. (2005). "Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing.". Cell Death Differ. 11 (5): 564–73. doi:10.1038/sj.cdd.4401391. PMID 14765135.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.