RTI-352

RTI-352 is a phenyltropane that is used as a radiolabeling ligand for the DAT. U.S. Patent 6,358,492

RTI-352 has been configured to have 1R,2S,3R stereochemistry and is therefore a geometric isomer of β-CIT.

Based on X-ray crystallography, this compound is in a tautomeric equilibrium residing mostly on the side of the boat-shaped conformer.

Synthesis

Phenyltropanes (classifications)

2-Carboxymethyl Esters	Troparil WIN 35428 RTI-31 RTI-32 RTI-51 RTI-55 RTI-83

(3,4-Disubstituted Phenyl)-tropanes	Dichloropane RTI-112 RTI-353

Arylcarboxy	RTI-113 RTI-120

Carboxyalkyl	RTI-121 RTI-150

Acyl	PTT/WF-11 WF-23 PIT/WF-21 WF-33

β,α Stereochemistry	RTI-352 RTI-274

α,β Stereochemistry	Brasofensine Tesofensine NS2359

Heterocycles: 3-Substituted-isoxazol-5-yl	RTI-177 RTI-336 RTI-371

Heterocycles: 3-Substituted-1,2,4-oxadiazole	RTI-126 RTI-371

N-alkyl	FP-β-CPPIT FE-β-CPPIT Altropane Ioflupane (¹²³I)

N-replaced (S,O,C)	Tropoxane

Irreversible	RTI-76

Nortropanes (N-demethylated)	NS2359 (GSK-372,475)