RSPO3
| R-spondin 3 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | RSPO3 ; CRISTIN1; PWTSR; THSD2 | ||||||||||||
| External IDs | OMIM: 610574 MGI: 1920030 HomoloGene: 12484 GeneCards: RSPO3 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 84870 | 72780 | |||||||||||
| Ensembl | ENSG00000146374 | ENSMUSG00000019880 | |||||||||||
| UniProt | Q9BXY4 | Q2TJ95 | |||||||||||
| RefSeq (mRNA) | NM_032784 | NM_028351 | |||||||||||
| RefSeq (protein) | NP_116173 | NP_082627 | |||||||||||
| Location (UCSC) | Chr 6: 127.44 – 127.52 Mb | Chr 10: 29.45 – 29.54 Mb | |||||||||||
| PubMed search | |||||||||||||
R-spondin-3 is a protein that in humans is encoded by the RSPO3 gene.[1][2][3]
This gene encodes a member of the thrombospondin type 1 repeat supergene family. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases.[3]
References
- ↑ Adams JC, Tucker RP (Aug 2000). "The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development". Dev Dyn 218 (2): 280–99. doi:10.1002/(SICI)1097-0177(200006)218:2<280::AID-DVDY4>3.0.CO;2-0. PMID 10842357.
- ↑ Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W (Oct 2004). "R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis". Dev Cell 7 (4): 525–34. doi:10.1016/j.devcel.2004.07.019. PMID 15469841.
- ↑ 3.0 3.1 "Entrez Gene: RSPO3 R-spondin 3 homolog (Xenopus laevis)".
Further reading
- Kim KA, Zhao J, Andarmani S et al. (2006). "R-Spondin proteins: a novel link to beta-catenin activation.". Cell Cycle 5 (1): 23–6. doi:10.4161/cc.5.1.2305. PMID 16357527.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Mungall AJ, Palmer SA, Sims SK et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Hannah BL, Misenheimer TM, Annis DS, Mosher DF (2003). "A polymorphism in thrombospondin-1 associated with familial premature coronary heart disease causes a local change in conformation of the Ca2+-binding repeats". J. Biol. Chem. 278 (11): 8929–34. doi:10.1074/jbc.M211185200. PMID 12643280.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Chen JZ, Wang S, Tang R et al. (2003). "Cloning and identification of a cDNA that encodes a novel human protein with thrombospondin type I repeat domain, hPWTSR". Mol. Biol. Rep. 29 (3): 287–92. doi:10.1023/A:1020479301379. PMID 12463421.