ROS1
Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene.[1][2]
Function
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.[2]
Interactions
ROS1 (gene) has been shown to interact with PTPN6.[3]
References
- ↑ Galland F, Stefanova M, Lafage M, Birnbaum D (July 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenetics and Cell Genetics 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909.
- ↑ 2.0 2.1 "Entrez Gene: ROS1 v-ros UR2 sarcoma virus oncogene homolog 1 (avian)".
- ↑ Keilhack H, Müller M, Böhmer SA, Frank C, Weidner KM, Birchmeier W et al. (Jan 2001). "Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1". The Journal of Cell Biology 152 (2): 325–34. doi:10.1083/jcb.152.2.325. PMC 2199605. PMID 11266449.
Further reading
- Birchmeier C, O'Neill K, Riggs M, Wigler M (Jun 1990). "Characterization of ROS1 cDNA from a human glioblastoma cell line". Proceedings of the National Academy of Sciences of the United States of America 87 (12): 4799–803. doi:10.1073/pnas.87.12.4799. PMC 54205. PMID 2352949.
- Sharma S, Birchmeier C, Nikawa J, O'Neill K, Rodgers L, Wigler M (1990). "Characterization of the ros1-gene products expressed in human glioblastoma cell lines". Oncogene Research 5 (2): 91–100. PMID 2691958.
- Birchmeier C, Sharma S, Wigler M (Dec 1987). "Expression and rearrangement of the ROS1 gene in human glioblastoma cells". Proceedings of the National Academy of Sciences of the United States of America 84 (24): 9270–4. doi:10.1073/pnas.84.24.9270. PMC 299735. PMID 2827175.
- Matsushime H, Wang LH, Shibuya M (Aug 1986). "Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule". Molecular and Cellular Biology 6 (8): 3000–4. PMC 367872. PMID 3023956.
- Satoh H, Yoshida MC, Matsushime H, Shibuya M, Sasaki M (Aug 1987). "Regional localization of the human c-ros-1 on 6q22 and flt on 13q12". Japanese Journal of Cancer Research 78 (8): 772–5. PMID 3115921.
- Birchmeier C, Birnbaum D, Waitches G, Fasano O, Wigler M (Sep 1986). "Characterization of an activated human ros gene". Molecular and Cellular Biology 6 (9): 3109–16. PMC 367045. PMID 3785223.
- Sonnenberg-Riethmacher E, Walter B, Riethmacher D, Gödecke S, Birchmeier C (May 1996). "The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis". Genes & Development 10 (10): 1184–93. doi:10.1101/gad.10.10.1184. PMID 8675006.
- Zeng L, Sachdev P, Yan L, Chan JL, Trenkle T, McClelland M et al. (Dec 2000). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Molecular and Cellular Biology 20 (24): 9212–24. doi:10.1128/MCB.20.24.9212-9224.2000. PMC 102179. PMID 11094073.
- Keilhack H, Müller M, Böhmer SA, Frank C, Weidner KM, Birchmeier W et al. (Jan 2001). "Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1". The Journal of Cell Biology 152 (2): 325–34. doi:10.1083/jcb.152.2.325. PMC 2199605. PMID 11266449.
- Charest A, Kheifets V, Park J, Lane K, McMahon K, Nutt CL et al. (Feb 2003). "Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma". Proceedings of the National Academy of Sciences of the United States of America 100 (3): 916–21. doi:10.1073/pnas.242741799. PMC 298701. PMID 12538861.
- Charest A, Lane K, McMahon K, Park J, Preisinger E, Conroy H et al. (May 2003). "Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)". Genes, Chromosomes & Cancer 37 (1): 58–71. doi:10.1002/gcc.10207. PMID 12661006.
- Légaré C, Sullivan R (Sep 2004). "Expression and localization of c-ros oncogene along the human excurrent duct". Molecular Human Reproduction 10 (9): 697–703. doi:10.1093/molehr/gah087. PMID 15235104.
- Biskup C, Böhmer A, Pusch R, Kelbauskas L, Gorshokov A, Majoul I et al. (Oct 2004). "Visualization of SHP-1-target interaction". Journal of Cell Science 117 (Pt 21): 5165–78. doi:10.1242/jcs.01397. PMID 15456853.
- Girish V, Sachdeva N, Minz RW, Radotra B, Mathuria SN, Arora SK (Jul 2005). "Bcl2 and ROS1 expression in human meningiomas: an analysis with respect to histological subtype". Indian Journal of Pathology & Microbiology 48 (3): 325–30. PMID 16761743.
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||