ROBO2

Roundabout, axon guidance receptor, homolog 2 (Drosophila)

PDB rendering based on 1uem.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1UEM, 1UJT, 2EDJ

Identifiers

ROBO2 ; SAX3

External IDs

OMIM: 602431 MGI: 1890110 HomoloGene: 43188 GeneCards: ROBO2 Gene

Gene ontology
Molecular function	• protein binding • axon guidance receptor activity • identical protein binding • protein heterodimerization activity
Cellular component	• cell surface • integral component of membrane • axolemma • extracellular vesicular exosome
Biological process	• metanephros development • ureteric bud development • homophilic cell adhesion • axon guidance • central nervous system development • brain development • axon midline choice point recognition • olfactory bulb interneuron development • retinal ganglion cell axon guidance • cellular response to hormone stimulus • positive regulation of axonogenesis • negative regulation of negative chemotaxis • negative regulation of synapse assembly • apoptotic process involved in luteolysis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000185008

ENSMUSG00000052516

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
75.96 – 77.7 Mb

Chr 16:
73.89 – 74.41 Mb

PubMed search

Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene.^[1]^[2]

References

↑ Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, Goodman CS, Tear G (Feb 1998). "Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors". Cell 92 (2): 205–15. doi:10.1016/S0092-8674(00)80915-0. PMID 9458045.
↑ "Entrez Gene: ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)".

Further reading

Brose K, Bland KS, Wang KH et al. (1999). "Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.". Cell 96 (6): 795–806. doi:10.1016/S0092-8674(00)80590-5. PMID 10102268.
Nguyen Ba-Charvet KT, Brose K, Marillat V et al. (1999). "Slit2-Mediated chemorepulsion and collapse of developing forebrain axons.". Neuron 22 (3): 463–73. doi:10.1016/S0896-6273(00)80702-3. PMID 10197527.
Nagase T, Kikuno R, Nakayama M et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
Nguyen Ba-Charvet KT, Brose K, Ma L et al. (2001). "Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance.". J. Neurosci. 21 (12): 4281–9. PMID 11404413.
Marillat V, Cases O, Nguyen-Ba-Charvet KT et al. (2002). "Spatiotemporal expression patterns of slit and robo genes in the rat brain.". J. Comp. Neurol. 442 (2): 130–55. doi:10.1002/cne.10068. PMID 11754167.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hivert B, Liu Z, Chuang CY et al. (2003). "Robo1 and Robo2 are homophilic binding molecules that promote axonal growth.". Mol. Cell. Neurosci. 21 (4): 534–45. doi:10.1006/mcne.2002.1193. PMID 12504588.
Grieshammer U, Le Ma , Plump AS et al. (2004). "SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site.". Dev. Cell 6 (5): 709–17. doi:10.1016/S1534-5807(04)00108-X. PMID 15130495.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yue Y, Grossmann B, Galetzka D et al. (2007). "Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice.". Genomics 88 (6): 772–8. doi:10.1016/j.ygeno.2006.05.011. PMID 16829019.
Lu W, van Eerde AM, Fan X et al. (2007). "Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.". Am. J. Hum. Genet. 80 (4): 616–32. doi:10.1086/512735. PMC 1852714. PMID 17357069.

PDB gallery

1uem: Solution Structure of the First Fibronectin Type III domain of human KIAA1568 Protein

1ujt: Solution structure of the second fibronectin Type III domain of human KIAA1568 protein