RNF25
| Ring finger protein 25 | |||||||||||||
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 PDB rendering based on 2day. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | RNF25 ; AO7 | ||||||||||||
| External IDs | MGI: 1890215 HomoloGene: 11193 GeneCards: RNF25 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 64320 | 57751 | |||||||||||
| Ensembl | ENSG00000163481 | ENSMUSG00000026171 | |||||||||||
| UniProt | Q96BH1 | Q9QZR0 | |||||||||||
| RefSeq (mRNA) | NM_022453 | NM_021313 | |||||||||||
| RefSeq (protein) | NP_071898 | NP_067288 | |||||||||||
| Location (UCSC) | Chr 2: 219.53 – 219.54 Mb | Chr 1: 74.59 – 74.6 Mb | |||||||||||
| PubMed search | |||||||||||||
E3 ubiquitin-protein ligase RNF25 is an enzyme that in humans is encoded by the RNF25 gene.[1][2]
Function
The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination.[2]
Interactions
RNF25 has been shown to interact with RELA.[1]
References
- ↑ 1.0 1.1 Asamitsu K, Tetsuka T, Kanazawa S, Okamoto T (Jul 2003). "RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit". J. Biol. Chem. 278 (29): 26879–87. doi:10.1074/jbc.M211831200. PMID 12748188.
- ↑ 2.0 2.1 "Entrez Gene: RNF25 ring finger protein 25".
Further reading
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S, Weissman AM (1999). "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11364–9. doi:10.1073/pnas.96.20.11364. PMC 18039. PMID 10500182.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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