RIPK2

Receptor-interacting serine-threonine kinase 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsRIPK2 ; CARD3; CARDIAK; CCK; GIG30; RICK; RIP2
External IDsOMIM: 603455 MGI: 1891456 HomoloGene: 37856 IUPHAR: 2190 ChEMBL: 5014 GeneCards: RIPK2 Gene
EC number2.7.10.2, 2.7.11.1
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez8767192656
EnsemblENSG00000104312ENSMUSG00000041135
UniProtO43353P58801
RefSeq (mRNA)NM_003821NM_138952
RefSeq (protein)NP_003812NP_620402
Location (UCSC)Chr 8:
90.77 – 90.8 Mb		Chr 4:
16.12 – 16.16 Mb
PubMed search

Receptor-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the RIPK2 gene.[1][2][3]

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-κB and inducer of apoptosis in response to various stimuli.[3]

Interactions

RIPK2 has been shown to interact with BIRC2.[2][4]

References

  1. ↑ Inohara N, del Peso L, Koseki T, Chen S, Nunez G (Jun 1998). "RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis". J Biol Chem 273 (20): 12296–300. doi:10.1074/jbc.273.20.12296. PMID 9575181.
  2. ↑ 2.0 2.1 Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J (Nov 1998). "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1". Curr Biol 8 (15): 885–8. doi:10.1016/S0960-9822(07)00352-1. PMID 9705938.
  3. ↑ 3.0 3.1 "Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2".
  4. ↑ McCarthy, J V; Ni J; Dixit V M (Jul 1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase". J. Biol. Chem. (UNITED STATES) 273 (27): 16968–75. doi:10.1074/jbc.273.27.16968. ISSN 0021-9258. PMID 9642260.

Further reading

  • Medzhitov R, Janeway C (2000). "Innate immune recognition: mechanisms and pathways". Immunol. Rev. 173: 89–97. doi:10.1034/j.1600-065X.2000.917309.x. PMID 10719670.
  • Dufner A, Mak TW (2006). "CARD tricks: controlling the interactions of CARD6 with RICK and microtubules". Cell Cycle 5 (8): 797–800. doi:10.4161/cc.5.8.2635. PMID 16582588.
  • McCarthy JV, Ni J, Dixit VM (1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase". J. Biol. Chem. 273 (27): 16968–75. doi:10.1074/jbc.273.27.16968. PMID 9642260.
  • Bertin J, Nir WJ, Fischer CM et al. (1999). "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB". J. Biol. Chem. 274 (19): 12955–8. doi:10.1074/jbc.274.19.12955. PMID 10224040.
  • Inohara N, Koseki T, del Peso L et al. (1999). "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB". J. Biol. Chem. 274 (21): 14560–7. doi:10.1074/jbc.274.21.14560. PMID 10329646.
  • Navas TA, Baldwin DT, Stewart TA (1999). "RIP2 is a Raf1-activated mitogen-activated protein kinase kinase". J. Biol. Chem. 274 (47): 33684–90. doi:10.1074/jbc.274.47.33684. PMID 10559258.
  • Inohara N, Koseki T, Lin J et al. (2000). "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways". J. Biol. Chem. 275 (36): 27823–31. doi:10.1074/jbc.M003415200. PMID 10880512.
  • Ogura Y, Inohara N, Benito A et al. (2001). "Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB". J. Biol. Chem. 276 (7): 4812–8. doi:10.1074/jbc.M008072200. PMID 11087742.
  • Lee SH, Stehlik C, Reed JC (2001). "Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing". J. Biol. Chem. 276 (37): 34495–500. doi:10.1074/jbc.M101415200. PMID 11432859.
  • Khursigara G, Bertin J, Yano H et al. (2001). "A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2". J. Neurosci. 21 (16): 5854–63. PMID 11487608.
  • Druilhe A, Srinivasula SM, Razmara M et al. (2001). "Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins". Cell Death Differ. 8 (6): 649–57. doi:10.1038/sj.cdd.4400881. PMID 11536016.
  • Chin AI, Dempsey PW, Bruhn K et al. (2002). "Involvement of receptor-interacting protein 2 in innate and adaptive immune responses". Nature 416 (6877): 190–4. doi:10.1038/416190a. PMID 11894097.
  • Kobayashi K, Inohara N, Hernandez LD et al. (2002). "RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems". Nature 416 (6877): 194–9. doi:10.1038/416194a. PMID 11894098.
  • Munz B, Hildt E, Springer ML, Blau HM (2002). "RIP2, a Checkpoint in Myogenic Differentiation". Mol. Cell. Biol. 22 (16): 5879–86. doi:10.1128/MCB.22.16.5879-5886.2002. PMC 133983. PMID 12138198.
  • Yoo NJ, Park WS, Kim SY et al. (2003). "Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1". Biochem. Biophys. Res. Commun. 299 (4): 652–8. doi:10.1016/S0006-291X(02)02714-6. PMID 12459189.
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Chen YR, Clark AC (2003). "Equilibrium and kinetic folding of an alpha-helical Greek key protein domain: caspase recruitment domain (CARD) of RICK". Biochemistry 42 (20): 6310–20. doi:10.1021/bi0340752. PMID 12755636.