RING1
E3 ubiquitin-protein ligase RING1 is an enzyme that in humans is encoded by the RING1 gene.[1][2]
This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4.[2]
Interactions
RING1 has been shown to interact with CBX8,[3] BMI1[4][5] and RYBP.[6][7]
References
- ↑ Hanson IM, Poustka A, Trowsdale J (August 1991). "New genes in the class II region of the human major histocompatibility complex". Genomics 10 (2): 417–24. doi:10.1016/0888-7543(91)90327-B. PMID 1906426.
- ↑ 2.0 2.1 "Entrez Gene: RING1 ring finger protein 1".
- ↑ Bárdos, J I; Saurin A J; Tissot C; Duprez E; Freemont P S (September 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J. Biol. Chem. (UNITED STATES) 275 (37): 28785–92. doi:10.1074/jbc.M001835200. ISSN 0021-9258. PMID 10825164.
- ↑ Satijn, D P; Gunster M J; van der Vlag J; Hamer K M; Schul W; Alkema M J; Saurin A J; Freemont P S; van Driel R; Otte A P (July 1997). "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor". Mol. Cell. Biol. (UNITED STATES) 17 (7): 4105–13. ISSN 0270-7306. PMC 232264. PMID 9199346.
- ↑ Satijn, D P; Otte A P (January 1999). "RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity". Mol. Cell. Biol. (UNITED STATES) 19 (1): 57–68. ISSN 0270-7306. PMC 83865. PMID 9858531.
- ↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ↑ García, E; Marcos-Gutiérrez C, del Mar Lorente M, Moreno J C, Vidal M (June 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. (ENGLAND) 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. ISSN 0261-4189. PMC 1171420. PMID 10369680.
Further reading
- Lovering R, Hanson IM, Borden KL et al. (1993). "Identification and preliminary characterization of a protein motif related to the zinc finger.". Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2112–6. doi:10.1073/pnas.90.6.2112. PMC 46035. PMID 7681583.
- Satijn DP, Gunster MJ, van der Vlag J et al. (1997). "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.". Mol. Cell. Biol. 17 (7): 4105–13. PMC 232264. PMID 9199346.
- Kikuti YY, Tamiya G, Ando A et al. (1997). "Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes.". Genomics 42 (3): 422–35. doi:10.1006/geno.1997.4745. PMID 9205114.
- Satijn DP, Otte AP (1999). "RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity.". Mol. Cell. Biol. 19 (1): 57–68. PMC 83865. PMID 9858531.
- García E, Marcos-Gutiérrez C, del Mar Lorente M et al. (1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1.". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.
- Bárdos JI, Saurin AJ, Tissot C et al. (2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties.". J. Biol. Chem. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. PMID 10825164.
- Trimarchi JM, Fairchild B, Wen J, Lees JA (2001). "The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex.". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1519–24. doi:10.1073/pnas.041597698. PMC 29289. PMID 11171983.
- Dahiya A, Wong S, Gonzalo S et al. (2001). "Linking the Rb and polycomb pathways.". Mol. Cell 8 (3): 557–69. doi:10.1016/S1097-2765(01)00346-X. PMID 11583618.
- Ogawa H, Ishiguro K, Gaubatz S et al. (2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.". Science 296 (5570): 1132–6. doi:10.1126/science.1069861. PMID 12004135.
- Akasaka T, Takahashi N, Suzuki M et al. (2003). "MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation.". Genes Cells 7 (8): 835–50. doi:10.1046/j.1365-2443.2002.00565.x. PMID 12167161.
- Levine SS, Weiss A, Erdjument-Bromage H et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.". Mol. Cell. Biol. 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Gil J, Bernard D, Martínez D, Beach D (2004). "Polycomb CBX7 has a unifying role in cellular lifespan.". Nat. Cell Biol. 6 (1): 67–72. doi:10.1038/ncb1077. PMID 14647293.
- Obuse C, Yang H, Nozaki N et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.". Genes Cells 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
- Wang H, Wang L, Erdjument-Bromage H et al. (2004). "Role of histone H2A ubiquitination in Polycomb silencing.". Nature 431 (7010): 873–8. doi:10.1038/nature02985. PMID 15386022.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Qin H, Du D, Zhu Y et al. (2005). "The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2.". FEBS Lett. 579 (5): 1220–6. doi:10.1016/j.febslet.2005.01.022. PMID 15710417.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
| |||||||||
External links
- RING1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||