RGS7

Regulator of G-protein signaling 7

PDB rendering based on 2a72.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2A72, 2D9J

Identifiers

Symbol

RGS7

External IDs

OMIM: 602517 MGI: 1346089 HomoloGene: 2193 IUPHAR: 2816 GeneCards: RGS7 Gene

Gene ontology
Molecular function	• signal transducer activity • GTPase activator activity • G-protein beta-subunit binding
Cellular component	• nucleus • cytoplasm • cytosol • heterotrimeric G-protein complex • plasma membrane • dendrite terminus
Biological process	• G-protein coupled receptor signaling pathway • intracellular signal transduction • termination of G-protein coupled receptor signaling pathway • positive regulation of GTPase activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
240.93 – 241.52 Mb

Chr 1:
175.06 – 175.49 Mb

PubMed search

Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene.^[1]^[2]

RGS7 is highly enriched in the brain where it acts as a universal inhibitor of Gi/o-coupled GPCR. RGS7 is a GTPase-activating protein (GAP). It accelerates the GTP hydrolysis on G proteins determining their fast inactivation and acting as intracellular antagonists of GPCR signaling.^[3]

Interactions

RGS7 has been shown to interact with:

References

↑ Koelle MR, Horvitz HR (Feb 1996). "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins". Cell 84 (1): 115–25. doi:10.1016/S0092-8674(00)80998-8. PMID 8548815.
↑ "Entrez Gene: RGS7 regulator of G-protein signalling 7".
↑ Anderson GR, Posokhova E, Martemyanov KA (July 2009). "The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling". Cell Biochemistry and Biophysics 54 (1-3): 33-46. doi:10.1007/s12013-009-9052-9. PMC 2827338. PMID 19521673.
↑ Levay K, Cabrera JL, Satpaev DK, Slepak VZ (Mar 1999). "Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. doi:10.1073/pnas.96.5.2503. PMC 26814. PMID 10051672.
↑ Posner BA, Gilman AG, Harris BA (Oct 1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. PMID 10521509.
↑ Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG et al. (June 11, 2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". J. Cell Biol. 197 (6): 711–9. doi:10.1083/jcb.201202123. PMC 3373406. PMID 22689652.
↑ Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O et al. (May 1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. doi:10.1073/pnas.96.11.6371. PMC 26888. PMID 10339594.
↑ Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH (Apr 2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun. 303 (2): 594–9. doi:10.1016/S0006-291X(03)00400-5. PMID 12659861.

Shuey DJ, Betty M, Jones PG, Khawaja XZ, Cockett MI (1998). "RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells". J. Neurochem. 70 (5): 1964–72. doi:10.1046/j.1471-4159.1998.70051964.x. PMID 9572280.
Levay K, Cabrera JL, Satpaev DK, Slepak VZ (1999). "Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. doi:10.1073/pnas.96.5.2503. PMC 26814. PMID 10051672.
Saitoh O, Kubo Y, Odagiri M, Ichikawa M, Yamagata K, Sekine T (1999). "RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents". J. Biol. Chem. 274 (14): 9899–904. doi:10.1074/jbc.274.14.9899. PMID 10092682.
Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O et al. (1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. doi:10.1073/pnas.96.11.6371. PMC 26888. PMID 10339594.
Snow BE, Betts L, Mangion J, Sondek J, Siderovski DP (1999). "Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. doi:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615.
Posner BA, Gilman AG, Harris BA (1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. PMID 10521509.
Benzing T, Yaffe MB, Arnould T, Sellin L, Schermer B, Schilling B et al. (2000). "14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity". J. Biol. Chem. 275 (36): 28167–72. doi:10.1074/jbc.M002905200. PMID 10862767.
Rose JJ, Taylor JB, Shi J, Cockett MI, Jones PG, Hepler JR (2000). "RGS7 is palmitoylated and exists as biochemically distinct forms". J. Neurochem. 75 (5): 2103–12. doi:10.1046/j.1471-4159.2000.0752103.x. PMID 11032900.
Zhang JH, Barr VA, Mo Y, Rojkova AM, Liu S, Simonds WF (2001). "Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain". J. Biol. Chem. 276 (13): 10284–9. doi:10.1074/jbc.M009247200. PMID 11152459.
Benzing T, Köttgen M, Johnson M, Schermer B, Zentgraf H, Walz G et al. (2002). "Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha". J. Biol. Chem. 277 (36): 32954–62. doi:10.1074/jbc.M200859200. PMID 12077120. Vancouver style error (help)
Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH (2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun. 303 (2): 594–9. doi:10.1016/S0006-291X(03)00400-5. PMID 12659861.
Witherow DS, Tovey SC, Wang Q, Willars GB, Slepak VZ (2003). "G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction". J. Biol. Chem. 278 (23): 21307–13. doi:10.1074/jbc.M212884200. PMID 12670932.
Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Takida S, Fischer CC, Wedegaertner PB (2005). "Palmitoylation and Plasma Membrane Targeting of RGS7 Are Promoted by αo". Mol. Pharmacol. 67 (1): 132–9. doi:10.1124/mol.104.003418. PMC 1405920. PMID 15496508.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Drenan RM, Doupnik CA, Jayaraman M, Buchwalter AL, Kaltenbronn KM, Huettner JE et al. (2006). "R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism". J. Biol. Chem. 281 (38): 28222–31. doi:10.1074/jbc.M604428200. PMID 16867977.

PDB gallery

2a72: Structure of the regulator of G-protein signaling domain of RGS7

2d9j: Solution structure of the RGS domain of Regulator of G-protein signaling 7

RGS7

Interactions

References

Further reading