RELB
Transcription factor RelB is a protein that in humans is encoded by the RELB gene.[1]
Interactions
RELB has been shown to interact with NFKB2,[2][3] NFKB1,[2] and C22orf25.[4]
See also
Further reading
- Taylor JP, Pomerantz R, Bagasra O et al. (1992). "TAR-independent transactivation by Tat in cells derived from the CNS: a novel mechanism of HIV-1 gene regulation". EMBO J. 11 (9): 3395–403. PMC 556874. PMID 1505523.
- Ruben SM, Klement JF, Coleman TA et al. (1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity". Genes Dev. 6 (5): 745–60. doi:10.1101/gad.6.5.745. PMID 1577270.
- Liu J, Perkins ND, Schmid RM, Nabel GJ (1992). "Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription". J. Virol. 66 (6): 3883–7. PMC 241175. PMID 1583734.
- Biswas DK, Salas TR, Wang F et al. (1996). "A Tat-induced auto-up-regulatory loop for superactivation of the human immunodeficiency virus type 1 promoter". J. Virol. 69 (12): 7437–44. PMC 189681. PMID 7494249.
- Jeang KT, Chun R, Lin NH et al. (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". J. Virol. 67 (10): 6224–33. PMC 238044. PMID 7690421.
- Alcamí J, Laín de Lera T, Folgueira L et al. (1995). "Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes". EMBO J. 14 (7): 1552–60. PMC 398242. PMID 7729429.
- Majello B, De Luca P, Hagen G et al. (1995). "Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1". Nucleic Acids Res. 22 (23): 4914–21. doi:10.1093/nar/22.23.4914. PMC 523756. PMID 7800480.
- Taylor JP, Pomerantz RJ, Oakes JW et al. (1995). "A CNS-enriched factor that binds to NF-kappa B and is required for interaction with HIV-1 tat". Oncogene 10 (2): 395–400. PMID 7838536.
- Westendorp MO, Shatrov VA, Schulze-Osthoff K et al. (1995). "HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state". EMBO J. 14 (3): 546–54. PMC 398112. PMID 7859743.
- Scala G, Ruocco MR, Ambrosino C et al. (1994). "The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein". J. Exp. Med. 179 (3): 961–71. doi:10.1084/jem.179.3.961. PMC 2191426. PMID 8113688.
- Bours V, Azarenko V, Dejardin E, Siebenlist U (1994). "Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins". Oncogene 9 (6): 1699–702. PMID 8183565.
- Deloukas P, Dauwerse JG, van Ommen GJ, van Loon AP (1994). "The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kappa B is located on chromosome 11q12". Genomics 19 (3): 592–4. doi:10.1006/geno.1994.1115. PMID 8188306.
- Westendorp MO, Li-Weber M, Frank RW, Krammer PH (1994). "Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells". J. Virol. 68 (7): 4177–85. PMC 236340. PMID 8207793.
- Dobrzanski P, Ryseck RP, Bravo R (1993). "Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif". Mol. Cell. Biol. 13 (3): 1572–82. PMC 359469. PMID 8441398.
- Harhaj E, Blaney J, Millhouse S, Sun SC (1996). "Differential effects of I kappa B molecules on Tat-mediated transactivation of HIV-1 LTR". Virology 216 (1): 284–7. doi:10.1006/viro.1996.0062. PMID 8615004.
- Conant K, Ma M, Nath A, Major EO (1996). "Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes". J. Virol. 70 (3): 1384–9. PMC 189957. PMID 8627654.
- Demarchi F, d'Adda di Fagagna F, Falaschi A, Giacca M (1996). "Activation of transcription factor NF-kappaB by the Tat protein of human immunodeficiency virus type 1". J. Virol. 70 (7): 4427–37. PMC 190376. PMID 8676466.
- Beauparlant P, Kwon H, Clarke M et al. (1996). "Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication". J. Virol. 70 (9): 5777–85. PMC 190591. PMID 8709193.
- Ramazzotti E, Vignoli M, Re MC et al. (1996). "Enhanced nuclear factor-kappa B activation induced by tumour necrosis factor-alpha in stably tat-transfected cells is associated with the presence of cell-surface-bound Tat protein". AIDS 10 (5): 455–61. doi:10.1097/00002030-199605000-00002. PMID 8724035.
References
- ↑ Bours V, Burd PR, Brown K, Villalobos J, Park S, Ryseck RP, Bravo R, Kelly K, Siebenlist U (Feb 1992). "A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site". Mol Cell Biol 12 (2): 685–95. PMC 364259. PMID 1531086.
- ↑ 2.0 2.1 Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216.
- ↑ Thornburg, Natalie J; Pathmanathan Rajadurai, Raab-Traub Nancy (Dec 2003). "Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma". Cancer Res. (United States) 63 (23): 8293–301. ISSN 0008-5472. PMID 14678988.
- ↑ "Molecular Interaction Database".
PDB gallery |
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| | 1zk9: NF-kB RelB forms an intertwined homodimer |
| 1zka: NF-kB RelB forms an intertwined homodimer, Y300S mutant |
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| | (2.1) Nuclear receptor (Cys4) | | subfamily 1 | |
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| | subfamily 2 | |
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| | subfamily 4 | |
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| | subfamily 5 | |
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| | subfamily 6 | |
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| | subfamily 0 | |
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| | (2.2) Other Cys4 | |
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| | (2.3) Cys2His2 | |
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| | (2.4) Cys6 | |
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| | (2.5) Alternating composition | |
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| | (2.6) WRKY | |
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| | | | | (4) β-Scaffold factors with minor groove contacts |
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| | | (0) Other transcription factors |
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| | see also transcription factor/coregulator deficiencies
Index of genetics |
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| | Description |
- Gene expression
- DNA
- replication
- cycle
- recombination
- repair
- binding proteins
- Transcription
- factors
- regulators
- nucleic acids
- RNA
- RNA binding proteins
- ribonucleoproteins
- repeated sequence
- modification
- Translation
- ribosome
- modification
- nexins
- Proteins
- domains
- Structure
- primary
- secondary
- tertiary
- quaternary
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| | Disease |
- Replication and repair
- Transcription factor
- Transcription
- Translation
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