RECQL5

RecQ protein-like 5

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
4BK0

Identifiers

Symbols

RECQL5 ; RECQ5

External IDs

OMIM: 603781 MGI: 2156841 HomoloGene: 31232 GeneCards: RECQL5 Gene

EC number

3.6.4.12

Gene ontology
Molecular function	• RNA polymerase II core binding • nucleic acid binding • DNA helicase activity • ATP binding • ATP-dependent helicase activity
Cellular component	• nucleus • nucleoplasm • nucleolus • cytoplasm • DNA-directed RNA polymerase II, holoenzyme • nuclear membrane
Biological process	• ATP catabolic process • DNA metabolic process • DNA replication • DNA repair • DNA recombination • mitotic nuclear division • DNA duplex unwinding • negative regulation of transcription elongation from RNA polymerase II promoter • chromosome separation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
73.62 – 73.66 Mb

Chr 11:
115.89 – 115.93 Mb

PubMed search

ATP-dependent DNA helicase Q5 is an enzyme that in humans is encoded by the RECQL5 gene.^[1]^[2]

Interactions

RECQL5 has been shown to interact with EEF1G.^[3]

References

↑ Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A (Dec 1998). "Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes". Genomics 54 (3): 443–52. doi:10.1006/geno.1998.5595. PMID 9878247.
↑ "Entrez Gene: RECQL5 RecQ protein-like 5".
↑ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H et al. (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

Sekelsky JJ, Brodsky MH, Rubin GM, Hawley RS (Sep 1999). "Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing". Nucleic Acids Research 27 (18): 3762–9. doi:10.1093/nar/27.18.3762. PMC 148633. PMID 10471747.
Shimamoto A, Nishikawa K, Kitao S, Furuichi Y (Apr 2000). "Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta". Nucleic Acids Research 28 (7): 1647–55. doi:10.1093/nar/28.7.1647. PMC 102787. PMID 10710432.
Garcia PL, Liu Y, Jiricny J, West SC, Janscak P (Jul 2004). "Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide". The EMBO Journal 23 (14): 2882–91. doi:10.1038/sj.emboj.7600301. PMC 514958. PMID 15241474.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H et al. (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Hu Y, Lu X, Barnes E, Yan M, Lou H, Luo G (May 2005). "Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers". Molecular and Cellular Biology 25 (9): 3431–42. doi:10.1128/MCB.25.9.3431-3442.2005. PMC 1084310. PMID 15831450.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R et al. (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Kanagaraj R, Saydam N, Garcia PL, Zheng L, Janscak P (2006). "Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork". Nucleic Acids Research 34 (18): 5217–31. doi:10.1093/nar/gkl677. PMC 1635296. PMID 17003056.
Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L et al. (Dec 2007). "RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments". Genes & Development 21 (23): 3073–84. doi:10.1101/gad.1609107. PMC 2081974. PMID 18003859.

RECQL5

Interactions

References

Further reading