RCC1

Regulator of chromosome condensation 1

PDB rendering based on 1a12.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1A12, 1I2M

Identifiers

Symbols

RCC1 ; CHC1; RCC1-I; SNHG3-RCC1

External IDs

OMIM: 179710 MGI: 1913989 HomoloGene: 55567 GeneCards: RCC1 Gene

Gene ontology
Molecular function	• chromatin binding • Ran guanyl-nucleotide exchange factor activity • protein binding • nucleosomal DNA binding • histone binding
Cellular component	• nuclear chromatin • condensed nuclear chromosome • nucleus • nucleoplasm • nucleolus • cytoplasm • nuclear membrane
Biological process	• G1/S transition of mitotic cell cycle • mitotic spindle organization • chromosome segregation • mitotic nuclear division • regulation of mitosis • viral process • positive regulation of Ran GTPase activity • spindle assembly
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
28.83 – 28.87 Mb

Chr 4:
132.33 – 132.35 Mb

PubMed search

Regulator of chromosome condensation 1, also known as RCC1, is the name for a human gene and protein.^[1]

RCC1 also functions as a guanine nucleotide exchange factor for Ran GTPase.

Interactions

RCC1 has been shown to interact with RANBP3^[2]^[3] and Ran (biology).^[4]^[5]^[6]^[7]

References

↑ "Entrez Gene: RCC1 Regulator of chromosome condensation 1".
↑ Nemergut, Michael E; Lindsay Mark E; Brownawell Amy M; Macara Ian G (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". J. Biol. Chem. (United States) 277 (20): 17385–8. doi:10.1074/jbc.C100620200. ISSN 0021-9258. PMID 11932251.
↑ Mueller, L; Cordes V C; Bischoff F R; Ponstingl H (May 1998). "Human RanBP3, a group of nuclear RanGTP binding proteins". FEBS Lett. (NETHERLANDS) 427 (3): 330–6. doi:10.1016/S0014-5793(98)00459-1. ISSN 0014-5793. PMID 9637251.
↑ Steggerda, S M; Paschal B M (July 2000). "The mammalian Mog1 protein is a guanine nucleotide release factor for Ran". J. Biol. Chem. (UNITED STATES) 275 (30): 23175–80. doi:10.1074/jbc.C000252200. ISSN 0021-9258. PMID 10811801.
↑ Renault, L; Kuhlmann J; Henkel A; Wittinghofer A (April 2001). "Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)". Cell (United States) 105 (2): 245–55. doi:10.1016/S0092-8674(01)00315-4. ISSN 0092-8674. PMID 11336674.
↑ Azuma, Y; Renault L; García-Ranea J A; Valencia A; Nishimoto T; Wittinghofer A (June 1999). "Model of the ran-RCC1 interaction using biochemical and docking experiments". J. Mol. Biol. (ENGLAND) 289 (4): 1119–30. doi:10.1006/jmbi.1999.2820. ISSN 0022-2836. PMID 10369786.
↑ Ren, M; Villamarin A; Shih A; Coutavas E; Moore M S; LoCurcio M; Clarke V; Oppenheim J D; D'Eustachio P; Rush M G (April 1995). "Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing". Mol. Cell. Biol. (UNITED STATES) 15 (4): 2117–24. ISSN 0270-7306. PMC 230439. PMID 7891706.

Furuno N, Nakagawa K, Eguchi U et al. (1992). "Complete nucleotide sequence of the human RCC1 gene involved in coupling between DNA replication and mitosis". Genomics 11 (2): 459–61. doi:10.1016/0888-7543(91)90156-9. PMID 1769659.
Bischoff FR, Ponstingl H (1991). "Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1". Nature 354 (6348): 80–2. doi:10.1038/354080a0. PMID 1944575.
Bischoff FR, Ponstingl H (1992). "Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide". Proc. Natl. Acad. Sci. U.S.A. 88 (23): 10830–4. doi:10.1073/pnas.88.23.10830. PMC 53025. PMID 1961752.
Bischoff FR, Maier G, Tilz G, Ponstingl H (1990). "A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1, a gene implicated in onset of chromosome condensation". Proc. Natl. Acad. Sci. U.S.A. 87 (21): 8617–21. doi:10.1073/pnas.87.21.8617. PMC 55008. PMID 2236072.
Ohtsubo M, Okazaki H, Nishimoto T (1989). "The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA". J. Cell Biol. 109 (4 Pt 1): 1389–97. doi:10.1083/jcb.109.4.1389. PMC 2115805. PMID 2677018.
Ohtsubo M, Kai R, Furuno N et al. (1987). "Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation". Genes Dev. 1 (6): 585–93. doi:10.1101/gad.1.6.585. PMID 3678831.
Hayashi N, Yokoyama N, Seki T et al. (1995). "RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4". Mol. Gen. Genet. 247 (6): 661–9. doi:10.1007/BF00290397. PMID 7616957.
Nishimoto T, Seino H, Seki N, Hori TA (1995). "The human CHC1 gene encoding RCC1 (regulator of chromosome condensation) (CHC1) is localized to human chromosome 1p36.1". Genomics 23 (3): 719–21. doi:10.1006/geno.1994.1570. PMID 7851910.
Miyabashira J, Sekiguchi T, Nishimoto T (1995). "Mammalian cells have two functional RCC1 proteins produced by alternative splicing". J. Cell. Sci. 107 (8): 2203–8. PMID 7983178.
Noguchi E, Hayashi N, Azuma Y et al. (1996). "Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1". EMBO J. 15 (20): 5595–605. PMC 452304. PMID 8896453.
Renault L, Nassar N, Vetter I et al. (1998). "The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller". Nature 392 (6671): 97–101. doi:10.1038/32204. PMID 9510255.
Renault L, Nassar N, Wittinghofer A et al. (1999). "Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation". Acta Crystallogr. D Biol. Crystallogr. 55 (Pt 1): 272–5. doi:10.1107/S0907444998007768. PMID 10089422.
Azuma Y, Renault L, García-Ranea JA et al. (1999). "Model of the ran-RCC1 interaction using biochemical and docking experiments". J. Mol. Biol. 289 (4): 1119–30. doi:10.1006/jmbi.1999.2820. PMID 10369786.
Talcott B, Moore MS (2000). "The nuclear import of RCC1 requires a specific nuclear localization sequence receptor, karyopherin alpha3/Qip". J. Biol. Chem. 275 (14): 10099–104. doi:10.1074/jbc.275.14.10099. PMID 10744690.
Nemergut ME, Macara IG (2000). "Nuclear Import of the Ran Exchange Factor, Rcc1, Is Mediated by at Least Two Distinct Mechanisms". J. Cell Biol. 149 (4): 835–50. doi:10.1083/jcb.149.4.835. PMC 2174574. PMID 10811825.
Fontoura BM, Blobel G, Yaseen NR (2000). "The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import". J. Biol. Chem. 275 (40): 31289–96. doi:10.1074/jbc.M004651200. PMID 10875935.
Freire J, Covelo G, Sarandeses C et al. (2001). "Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha". Biochem. Cell Biol. 79 (2): 123–31. doi:10.1139/bcb-79-2-123. PMID 11310559.
Renault L, Kuhlmann J, Henkel A, Wittinghofer A (2001). "Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)". Cell 105 (2): 245–55. doi:10.1016/S0092-8674(01)00315-4. PMID 11336674.
Nemergut ME, Mizzen CA, Stukenberg T et al. (2001). "Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B". Science 292 (5521): 1540–3. doi:10.1126/science.292.5521.1540. PMID 11375490.
Nemergut ME, Lindsay ME, Brownawell AM, Macara IG (2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". J. Biol. Chem. 277 (20): 17385–8. doi:10.1074/jbc.C100620200. PMID 11932251.

PDB gallery

1a12: REGULATOR OF CHROMOSOME CONDENSATION (RCC1) OF HUMAN

1i2m: RAN-RCC1-SO4 COMPLEX

RCC1

Interactions

References

Further reading