RBX1
RING-box protein 1 is a protein that in humans is encoded by the RBX1 gene.[1][2]
This gene encodes an evolutionarily conserved protein that interacts with cullins. The protein plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over.[3]
Interactions
RBX1 has been shown to interact with CUL4A,[2][4][5] CAND1,[6][7] CUL1,[2][4][6][7][8][9] CUL2,[2][4] P70-S6 Kinase 1,[10] DCUN1D1,[7] CUL5[2][11] and CUL7.[4]
References
- ↑ Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin WG Jr, Elledge SJ, Conaway RC, Harper JW, Conaway JW (May 1999). "Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase". Science 284 (5414): 657–61. doi:10.1126/science.284.5414.657. PMID 10213691.
- ↑ 2.0 2.1 2.2 2.3 2.4 Ohta T, Michel JJ, Schottelius AJ, Xiong Y (May 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol Cell 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. PMID 10230407.
- ↑ "Entrez Gene: RBX1 ring-box 1".
- ↑ 4.0 4.1 4.2 4.3 Dias, Dora C; Dolios Georgia; Wang Rong; Pan Zhen-Qiang (Dec 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (26): 16601–6. doi:10.1073/pnas.252646399. ISSN 0027-8424. PMC 139190. PMID 12481031.
- ↑ Guerrero-Santoro, Jennifer; Kapetanaki Maria G, Hsieh Ching L, Gorbachinsky Ilya, Levine Arthur S, Rapić-Otrin Vesna (Jul 2008). "The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A". Cancer Res. (United States) 68 (13): 5014–22. doi:10.1158/0008-5472.CAN-07-6162. PMID 18593899.
- ↑ 6.0 6.1 Min, Kyoeng-Woo; Hwang Ji-Won; Lee Jong-Sik; Park Yoon; Tamura Taka-aki; Yoon Jong-Bok (May 2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity". J. Biol. Chem. (United States) 278 (18): 15905–10. doi:10.1074/jbc.M213070200. ISSN 0021-9258. PMID 12609982.
- ↑ 7.0 7.1 7.2 Kim, Alexander Y; Bommeljé Claire C, Lee Benjamin E, Yonekawa Yoshihiro, Choi Lydia, Morris Luc G, Huang Guochang, Kaufman Andrew, Ryan Russel J H, Hao Bing, Ramanathan Y, Singh Bhuvanesh (Nov 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". J. Biol. Chem. (United States) 283 (48): 33211–20. doi:10.1074/jbc.M804440200. ISSN 0021-9258. PMC 2586271. PMID 18826954.
- ↑ Kim, Jaehoon; Kim Jeong-Hoon; Lee Sung-Hak; Kim Do-Hyung; Kang Ho-Young; Bae Sung-Ho; Pan Zhen-Qiang; Seo Yeon-Soo (Jul 2002). "The novel human DNA helicase hFBH1 is an F-box protein". J. Biol. Chem. (United States) 277 (27): 24530–7. doi:10.1074/jbc.M201612200. ISSN 0021-9258. PMID 11956208.
- ↑ Zheng, Ning; Schulman Brenda A, Song Langzhou, Miller Julie J, Jeffrey Philip D, Wang Ping, Chu Claire, Koepp Deanna M, Elledge Stephen J, Pagano Michele, Conaway Ronald C, Conaway Joan W, Harper J Wade, Pavletich Nikola P (Apr 2002). "Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex". Nature (England) 416 (6882): 703–9. doi:10.1038/416703a. ISSN 0028-0836. PMID 11961546.
- ↑ Panasyuk, Ganna; Nemazanyy Ivan; Filonenko Valeriy; Gout Ivan (May 2008). "Ribosomal protein S6 kinase 1 interacts with and is ubiquitinated by ubiquitin ligase ROC1". Biochem. Biophys. Res. Commun. (United States) 369 (2): 339–43. doi:10.1016/j.bbrc.2008.02.016. PMID 18279656.
- ↑ Duda, David M; Borg Laura A; Scott Daniel C; Hunt Harold W; Hammel Michal; Schulman Brenda A (Sep 2008). "Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation". Cell (United States) 134 (6): 995–1006. doi:10.1016/j.cell.2008.07.022. PMC 2628631. PMID 18805092.
Further reading
- Skowyra D, Koepp DM, Kamura T et al. (1999). "Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.". Science 284 (5414): 662–5. doi:10.1126/science.284.5414.662. PMID 10213692.
- Tan P, Fuchs SY, Chen A et al. (1999). "Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha.". Mol. Cell 3 (4): 527–33. doi:10.1016/S1097-2765(00)80481-5. PMID 10230406.
- Winston JT, Koepp DM, Zhu C et al. (1999). "A family of mammalian F-box proteins.". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
- Kamura T, Conrad MN, Yan Q et al. (2000). "The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2.". Genes Dev. 13 (22): 2928–33. doi:10.1101/gad.13.22.2928. PMC 317157. PMID 10579999.
- Dunham I, Shimizu N, Roe BA et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- Périn J-P , Seddiqi N, Charbonnier F et al. (2000). "Genomic organization and expression of the ubiquitin-proteasome complex-associated protein Rbx1/ROC1/Hrt1.". Cell. Mol. Biol. (Noisy-le-grand) 45 (8): 1131–7. PMID 10643962.
- Read MA, Brownell JE, Gladysheva TB et al. (2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha.". Mol. Cell. Biol. 20 (7): 2326–33. doi:10.1128/MCB.20.7.2326-2333.2000. PMC 85397. PMID 10713156.
- Furukawa M, Zhang Y, McCarville J et al. (2000). "The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1.". Mol. Cell. Biol. 20 (21): 8185–97. doi:10.1128/MCB.20.21.8185-8197.2000. PMC 86428. PMID 11027288.
- Maeda I, Ohta T, Koizumi H, Fukuda M (2001). "In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3.". FEBS Lett. 494 (3): 181–5. doi:10.1016/S0014-5793(01)02343-2. PMID 11311237.
- Lyapina S, Cope G, Shevchenko A et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.". Science 292 (5520): 1382–5. doi:10.1126/science.1059780. PMID 11337588.
- Fukuchi M, Imamura T, Chiba T et al. (2001). "Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins.". Mol. Biol. Cell 12 (5): 1431–43. doi:10.1091/mbc.12.5.1431. PMC 34595. PMID 11359933.
- Kamura T, Burian D, Yan Q et al. (2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.". J. Biol. Chem. 276 (32): 29748–53. doi:10.1074/jbc.M103093200. PMID 11384984.
- Wu K, Chen A, Tan P, Pan ZQ (2002). "The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34.". J. Biol. Chem. 277 (1): 516–27. doi:10.1074/jbc.M108008200. PMID 11675391.
- Gomes MD, Lecker SH, Jagoe RT et al. (2002). "Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy.". Proc. Natl. Acad. Sci. U.S.A. 98 (25): 14440–5. doi:10.1073/pnas.251541198. PMC 64700. PMID 11717410.
- Kim J, Kim JH, Lee SH et al. (2002). "The novel human DNA helicase hFBH1 is an F-box protein.". J. Biol. Chem. 277 (27): 24530–7. doi:10.1074/jbc.M201612200. PMID 11956208.
- Zheng N, Schulman BA, Song L et al. (2002). "Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.". Nature 416 (6882): 703–9. doi:10.1038/416703a. PMID 11961546.
- Yoshida Y, Chiba T, Tokunaga F et al. (2002). "E3 ubiquitin ligase that recognizes sugar chains.". Nature 418 (6896): 438–42. doi:10.1038/nature00890. PMID 12140560.
- Brower CS, Sato S, Tomomori-Sato C et al. (2002). "Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.". Proc. Natl. Acad. Sci. U.S.A. 99 (16): 10353–8. doi:10.1073/pnas.162424199. PMC 124918. PMID 12149480.
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