RBM39
| RNA binding motif protein 39 | |||||||||||||
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 PDB rendering based on 2cq4. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | RBM39 ; CAPER; CAPERalpha; FSAP59; HCC1; RNPC2 | ||||||||||||
| External IDs | OMIM: 604739 MGI: 2157953 HomoloGene: 136465 GeneCards: RBM39 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9584 | 170791 | |||||||||||
| Ensembl | ENSG00000131051 | ENSMUSG00000027620 | |||||||||||
| UniProt | Q14498 | Q8VH51 | |||||||||||
| RefSeq (mRNA) | NM_001242599 | NM_001291114 | |||||||||||
| RefSeq (protein) | NP_001229528 | NP_001278043 | |||||||||||
| Location (UCSC) | Chr 20: 34.29 – 34.33 Mb | Chr 2: 156.15 – 156.18 Mb | |||||||||||
| PubMed search | |||||||||||||
RNA-binding protein 39 is a protein that in humans is encoded by the RBM39 gene.[1][2]
Function
The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this protein suggest that this protein may act as a transcriptional coactivator for JUN/AP-1 and estrogen receptors. Multiple transcript variants encoding different isoforms have been observed for this gene.[2]
Interactions
RBM39 has been shown to interact with Estrogen receptor alpha,[3] Estrogen receptor beta[3] and C-jun.[3]
References
- ↑ Imai H, Chan EK, Kiyosawa K, Fu XD, Tan EM (Dec 1993). "Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma". J Clin Invest 92 (5): 2419–26. doi:10.1172/JCI116848. PMC 288425. PMID 8227358.
- ↑ 2.0 2.1 "Entrez Gene: RBM39 RNA binding motif protein 39".
- ↑ 3.0 3.1 3.2 Jung DJ, Na SY, Na DS, Lee JW (Jan 2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. 277 (2): 1229–34. doi:10.1074/jbc.M110417200. PMID 11704680.
Further reading
- Jung DJ, Na SY, Na DS, Lee JW (2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. 277 (2): 1229–34. doi:10.1074/jbc.M110417200. PMID 11704680.
- Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Dowhan DH, Hong EP, Auboeuf D, Dennis AP, Wilson MM, Berget SM et al. (2005). "Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta". Mol. Cell 17 (3): 429–39. doi:10.1016/j.molcel.2004.12.025. PMID 15694343.
- Sun NN, Fastje CD, Wong SS, Sheppard PR, Macdonald SJ, Ridenour G et al. (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line". Toxicology and industrial health 19 (7–10): 157–63. doi:10.1191/0748233703th185oa. PMID 15747776.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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