RBM14

RNA binding motif protein 14

PDB rendering based on 2dnp.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2DNP

Identifiers

Symbols

RBM14 ; COAA; PSP2; SIP; SYTIP1; TMEM137

External IDs

OMIM: 612409 MGI: 1929092 HomoloGene: 4614 GeneCards: RBM14 Gene

Gene ontology
Molecular function	• nucleotide binding • RNA polymerase II transcription cofactor activity • RNA binding • protein binding • ligand-dependent nuclear receptor transcription coactivator activity • protein binding, bridging • poly(A) RNA binding
Cellular component	• nucleus • transcription factor complex • nucleolus • mediator complex • ribonucleoprotein complex
Biological process	• DNA replication • DNA repair • DNA recombination • transcription from RNA polymerase II promoter • response to hormone • histone deacetylation • intracellular estrogen receptor signaling pathway • glucocorticoid receptor signaling pathway • positive regulation of transcription from RNA polymerase II promoter
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
66.38 – 66.39 Mb

Chr 19:
4.8 – 4.81 Mb

PubMed search

RNA-binding protein 14 is a protein that in humans is encoded by the RBM14 gene.^[1]^[2]

Interactions

RBM14 has been shown to interact with TARBP2.^[3]

References

↑ Brett D, Whitehouse S, Antonson P, Shipley J, Cooper C, Goodwin G (February 1998). "The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies". Hum Mol Genet 6 (9): 1559–64. doi:10.1093/hmg/6.9.1559. PMID 9285794.
↑ "Entrez Gene: RBM14 RNA binding motif protein 14".
↑ Iwasaki T, Chin WW, Ko L (September 2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". J. Biol. Chem. 276 (36): 33375–83. doi:10.1074/jbc.M101517200. PMID 11443112.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Iwasaki T, Chin WW, Ko L (2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM).". J. Biol. Chem. 276 (36): 33375–83. doi:10.1074/jbc.M101517200. PMID 11443112.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. Vancouver style error (help)
Perani M, Antonson P, Hamoudi R, Ingram CJ, Cooper CS, Garrett MD et al. (2006). "The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins.". J. Biol. Chem. 280 (52): 42863–76. doi:10.1074/jbc.M502963200. PMID 16227627.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. Vancouver style error (help)
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. Vancouver style error (help)
Sui Y, Yang Z, Xiong S, Zhang L, Blanchard KL, Peiper SC et al. (2007). "Gene amplification and associated loss of 5' regulatory sequences of CoAA in human cancers.". Oncogene 26 (6): 822–35. doi:10.1038/sj.onc.1209847. PMID 16878147.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. Vancouver style error (help)
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Yang Z, Sui Y, Xiong S, Liour SS, Phillips AC, Ko L (2007). "Switched alternative splicing of oncogene CoAA during embryonal carcinoma stem cell differentiation.". Nucleic Acids Res. 35 (6): 1919–32. doi:10.1093/nar/gkl1092. PMC 1874587. PMID 17337438.

PDB gallery

2dnp: Solution structure of RNA binding domain 2 in RNA-binding protein 14

RBM14

Interactions

References

Further reading