RB1CC1

RB1-inducible coiled-coil 1

Identifiers

RB1CC1 ; ATG17; CC1; FIP200; PPP1R131

External IDs

OMIM: 606837 MGI: 1341850 HomoloGene: 7659 GeneCards: RB1CC1 Gene

Gene ontology
Molecular function	• protein binding • protein kinase binding
Cellular component	• cytoplasm • cytosol • nuclear membrane • pre-autophagosomal structure membrane • ULK1-ATG13-FIP200 complex
Biological process	• autophagic vacuole assembly • liver development • positive regulation of protein phosphorylation • transcription, DNA-templated • regulation of transcription, DNA-templated • cell cycle • JNK cascade • heart development • regulation of autophagy • negative regulation of apoptotic process • positive regulation of cell size • negative regulation of extrinsic apoptotic signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
53.54 – 53.66 Mb

Chr 1:
6.21 – 6.28 Mb

PubMed search

RB1-inducible coiled-coil protein 1 is a protein that in humans is encoded by the RB1CC1 gene.^[1]^[2]^[3]^[4]

Interactions

RB1CC1 has been shown to interact with PTK2B,^[5] ASK1^[6] and PTK2.^[5]

References

↑ Chano T, Ikegawa S, Kontani K, Okabe H, Baldini N, Saeki Y (February 2002). "Identification of RB1CC1, a novel human gene that can induce RB1 in various human cells". Oncogene 21 (8): 1097–1107. doi:10.1038/sj.onc.1205171. PMID 11850849.
↑ Maucuer A, Camonis JH, Sobel A (May 1995). "Stathmin interaction with a putative kinase and coiled-coil-forming protein domains". Proc Natl Acad Sci U S A 92 (8): 3100–3104. doi:10.1073/pnas.92.8.3100. PMC 42112. PMID 7724523.
↑ Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N (May 2008). "FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells". J Cell Biol 181 (3): 497–510. doi:10.1083/jcb.200712064. PMC 2364687. PMID 18443221.
↑ "Entrez Gene: RB1CC1 RB1-inducible coiled-coil 1".
↑ 5.0 5.1 Ueda, H; Abbi S; Zheng C; Guan J L (April 2000). "Suppression of Pyk2 kinase and cellular activities by FIP200". J. Cell Biol. (UNITED STATES) 149 (2): 423–430. doi:10.1083/jcb.149.2.423. ISSN 0021-9525. PMC 2175150. PMID 10769033.
↑ Gan, Boyi; Peng Xu; Nagy Tamas; Alcaraz Ana; Gu Hua; Guan Jun-Lin (October 2006). "Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways". J. Cell Biol. (United States) 175 (1): 121–133. doi:10.1083/jcb.200604129. ISSN 0021-9525. PMC 2064504. PMID 17015619.

Nagase T; Seki N; Ishikawa K et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–329. doi:10.1093/dnares/3.5.321. PMID 9039502.
Ueda H, Abbi S, Zheng C, Guan JL (2000). "Suppression of Pyk2 kinase and cellular activities by FIP200". J. Cell Biol. 149 (2): 423–430. doi:10.1083/jcb.149.2.423. PMC 2175150. PMID 10769033.
Chano T; Kontani K; Teramoto K et al. (2002). "Truncating mutations of RB1CC1 in human breast cancer". Nat. Genet. 31 (3): 285–288. doi:10.1038/ng911. PMID 12068296.
Chano T; Ikegawa S; Saito-Ohara F et al. (2002). "Isolation, characterization and mapping of the mouse and human RB1CC1 genes". Gene 291 (1–2): 29–34. doi:10.1016/S0378-1119(02)00585-1. PMID 12095676.
Chano T; Saeki Y; Serra M et al. (2002). "Preferential expression of RB1-inducible coiled-coil 1 in terminal differentiated musculoskeletal cells". Am. J. Pathol. 161 (2): 359–64. doi:10.1016/S0002-9440(10)64190-9. PMC 1850752. PMID 12163359.
Abbi S; Ueda H; Zheng C et al. (2003). "Regulation of focal adhesion kinase by a novel protein inhibitor FIP200". Mol. Biol. Cell 13 (9): 3178–3191. doi:10.1091/mbc.E02-05-0295. PMC 124151. PMID 12221124.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kontani K; Chano T; Ozaki Y et al. (2004). "RB1CC1 suppresses cell cycle progression through RB1 expression in human neoplastic cells". Int. J. Mol. Med. 12 (5): 767–9. doi:10.3892/ijmm.12.5.767. PMID 14533007.
Bamba N; Chano T; Taga T et al. (2005). "Expression and regulation of RB1CC1 in developing murine and human tissues". Int. J. Mol. Med. 14 (4): 583–7. doi:10.3892/ijmm.14.4.583. PMID 15375585.
Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Watanabe R; Chano T; Inoue H et al. (2005). "Rb1cc1 is critical for myoblast differentiation through Rb1 regulation". Virchows Arch. 447 (3): 643–648. doi:10.1007/s00428-004-1183-1. PMID 15968549.
Gan B; Melkoumian ZK; Wu X et al. (2005). "Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control". J. Cell Biol. 170 (3): 379–389. doi:10.1083/jcb.200411106. PMC 2171462. PMID 16043512.
Melkoumian ZK; Peng X; Gan B et al. (2005). "Mechanism of cell cycle regulation by FIP200 in human breast cancer cells". Cancer Res. 65 (15): 6676–6684. doi:10.1158/0008-5472.CAN-04-4142. PMID 16061648.
Kimura K; Wakamatsu A; Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Chano T; Saji M; Inoue H et al. (2006). "Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation". Int. J. Mol. Med. 18 (3): 425–32. doi:10.3892/ijmm.18.3.425. PMID 16865226.
Olsen JV; Blagoev B; Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM; Chu P; Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Lee YC, Yang VC, Wang TS (2007). "Use of RAPD to detect sodium arsenite-induced DNA damage in human lymphoblastoid cells". Toxicology 239 (1–2): 108–115. doi:10.1016/j.tox.2007.06.101. PMID 17707572.

RB1CC1

Interactions

References

Further reading