RASSF1

Ras association (RalGDS/AF-6) domain family member 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2KZU
Identifiers
Symbols	RASSF1 ; 123F2; NORE2A; RASSF1A; RDA32; REH3P21
External IDs	OMIM: 605082 HomoloGene: 10499 GeneCards: RASSF1 Gene
Gene ontology Molecular function • protein binding • zinc ion binding • identical protein binding • protein N-terminus binding Cellular component • spindle pole • nucleus • cytoplasm • microtubule organizing center • microtubule • plasma membrane • microtubule cytoskeleton Biological process • cellular response to DNA damage stimulus • cell cycle arrest • Ras protein signal transduction • positive regulation of protein ubiquitination • protein stabilization • negative regulation of cell cycle arrest Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11186	56289
Ensembl	ENSG00000068028	ENSMUSG00000010067
UniProt	Q9NS23	Q99MK9
RefSeq (mRNA)	NM_001206957	NM_001243748
RefSeq (protein)	NP_001193886	NP_001230677
Location (UCSC)	Chr 3: 50.37 – 50.38 Mb	Chr 9: 107.55 – 107.56 Mb
PubMed search

Ras association domain-containing protein 1 is a protein that in humans is encoded by the RASSF1 gene.

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.^[1]

Interactions

RASSF1 has been shown to interact with MAP1B,^[2] RASSF5,^[3] CNKSR1,^[4] HRAS,^[5] Death associated protein 6^[6] and MAP1S.^[2][7]

References